Reaction Details |
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Target | Procathepsin L |
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Ligand | BDBM19804 |
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Substrate/Competitor | BDBM19485 |
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Meas. Tech. | In Vitro Enzyme Inhibition Assay |
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Ki | 250±n/a nM |
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Citation | Marquis, RW; Ru, Y; Zeng, J; Trout, RE; LoCastro, SM; Gribble, AD; Witherington, J; Fenwick, AE; Garnier, B; Tomaszek, T; Tew, D; Hemling, ME; Quinn, CJ; Smith, WW; Zhao, B; McQueney, MS; Janson, CA; D'Alessio, K; Veber, DF Cyclic ketone inhibitors of the cysteine protease cathepsin K. J Med Chem44:725-36 (2001) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Procathepsin L |
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Name: | Procathepsin L |
Synonyms: | CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein |
Type: | Enzyme |
Mol. Mass.: | 37557.19 |
Organism: | Homo sapiens (Human) |
Description: | Purchased from Calbiochem (San Diego, CA). |
Residue: | 333 |
Sequence: | MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
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BDBM19804 |
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BDBM19485 |
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Name | BDBM19804 |
Synonyms: | (2S)-4-methyl-N-(4-oxooxolan-3-yl)-2-(quinolin-2-ylformamido)pentanamide | 3-amidotetrahydrofuran-4-one, 16 | CHEMBL62239 |
Type | Small organic molecule |
Emp. Form. | C20H23N3O4 |
Mol. Mass. | 369.4143 |
SMILES | CC(C)C[C@H](NC(=O)c1ccc2ccccc2n1)C(=O)NC1COCC1=O |r| |
Structure |
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