| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin S |
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| Ligand | BDBM19807 |
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| Substrate/Competitor | BDBM19490 |
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| Meas. Tech. | In Vitro Enzyme Inhibition Assay |
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| Ki | 90±n/a nM |
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| Citation |  Marquis, RW; Ru, Y; Zeng, J; Trout, RE; LoCastro, SM; Gribble, AD; Witherington, J; Fenwick, AE; Garnier, B; Tomaszek, T; Tew, D; Hemling, ME; Quinn, CJ; Smith, WW; Zhao, B; McQueney, MS; Janson, CA; D'Alessio, K; Veber, DF Cyclic ketone inhibitors of the cysteine protease cathepsin K. J Med Chem44:725-36 (2001) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Cathepsin S |
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| Name: | Cathepsin S |
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| Synonyms: | CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein |
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| Type: | Protein |
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| Mol. Mass.: | 37507.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25774 |
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| Residue: | 331 |
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| Sequence: | MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
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| BDBM19807 |
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| BDBM19490 |
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| Name | BDBM19807 |
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| Synonyms: | CHEMBL100563 | benzyl N-[(1S)-1-({1-[(2S)-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoyl]-4-oxopyrrolidin-3-yl}carbamoyl)-3-methylbutyl]carbamate | pyrrolidinone analogue, 24 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H42N4O7 |
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| Mol. Mass. | 594.6985 |
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| SMILES | CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NC1CN(CC1=O)C(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 |r| |
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| Structure | 
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