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TargetOxysterols receptor LXR-beta [154-461]
LigandBDBM20005
Substrate/CompetitorBDBM19993
Meas. Tech.LXR Binding Assay
IC50 4.3±n/a nM
EC50 100±n/a nM
Citation Hu, BJetter, JKaufman, DSinghaus, RBernotas, RUnwalla, RQuinet, ESavio, DHalpern, ABasso, MKeith, JClerin, VChen, LLiu, QYFeingold, IHuselton, CAzam, FGoos-Nilsson, AWilhelmsson, ANambi, PWrobel, J Further modification on phenyl acetic acid based quinolines as liver X receptor modulators. Bioorg Med Chem15:3321-33 (2007) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Oxysterols receptor LXR-beta [154-461]
Name:Oxysterols receptor LXR-beta [154-461]
Synonyms:LXRB | Liver X Receptor beta (LXR-beta) | NER | NR1H2 | NR1H2_HUMAN | Nuclear orphan receptor LXR-beta | Nuclear receptor NER | Nuclear receptor subfamily 1 group H member 2 | Oxysterols receptor LXR-beta | UNR | Ubiquitously-expressed nuclear receptor
Type:Receptor
Mol. Mass.:34695.52
Organism:Homo sapiens (Human)
Description:LXR beta ligand binding domain (amino acid residues 154-461) with an N-terminal biotinylation tag expressed in E.coli, was used for the binding assays.
Residue:308
Sequence:
MREQCVLSEEQIRKKKIRKQQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGS
GEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFT
ELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKD
FTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRV
EALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPL
LSEIWDVH
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BDBM20005
BDBM19993
NameBDBM20005
Synonyms:2-{4-[({3-[3-methyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl]phenyl}acetic acid | phenyl acetic acid based quinoline, 17
TypeSmall organic molecule
Emp. Form.C26H21F3N2O2
Mol. Mass.450.4523
SMILESCc1cnc2c(cccc2c1-c1cccc(NCc2ccc(CC(O)=O)cc2)c1)C(F)(F)F
Structure
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