| Reaction Details |
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 | Report a problem with these data |
| Target | Oxysterols receptor LXR-beta [154-461] |
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| Ligand | BDBM20010 |
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| Substrate/Competitor | BDBM19993 |
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| Meas. Tech. | LXR Binding Assay |
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| IC50 | 5.5±n/a nM |
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| EC50 | 61±n/a nM |
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| Citation |  Hu, B; Jetter, J; Kaufman, D; Singhaus, R; Bernotas, R; Unwalla, R; Quinet, E; Savio, D; Halpern, A; Basso, M; Keith, J; Clerin, V; Chen, L; Liu, QY; Feingold, I; Huselton, C; Azam, F; Goos-Nilsson, A; Wilhelmsson, A; Nambi, P; Wrobel, J Further modification on phenyl acetic acid based quinolines as liver X receptor modulators. Bioorg Med Chem15:3321-33 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Oxysterols receptor LXR-beta [154-461] |
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| Name: | Oxysterols receptor LXR-beta [154-461] |
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| Synonyms: | LXRB | Liver X Receptor beta (LXR-beta) | NER | NR1H2 | NR1H2_HUMAN | Nuclear orphan receptor LXR-beta | Nuclear receptor NER | Nuclear receptor subfamily 1 group H member 2 | Oxysterols receptor LXR-beta | UNR | Ubiquitously-expressed nuclear receptor |
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| Type: | Receptor |
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| Mol. Mass.: | 34695.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | LXR beta ligand binding domain (amino acid residues 154-461) with an N-terminal biotinylation tag expressed in E.coli, was used for the binding assays. |
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| Residue: | 308 |
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| Sequence: | MREQCVLSEEQIRKKKIRKQQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGS
GEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFT
ELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKD
FTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRV
EALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPL
LSEIWDVH
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| BDBM20010 |
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| BDBM19993 |
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| Name | BDBM20010 |
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| Synonyms: | 2-[4-({[3-(3-benzoyl-8-methylquinolin-4-yl)phenyl]amino}methyl)phenyl]acetic acid | phenyl acetic acid based quinoline, 22 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H26N2O3 |
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| Mol. Mass. | 486.5604 |
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| SMILES | Cc1cccc2c(-c3cccc(NCc4ccc(CC(O)=O)cc4)c3)c(cnc12)C(=O)c1ccccc1 |
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| Structure | 
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