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TargetThymidine phosphorylase
LigandBDBM20061
Substrate/CompetitorBDBM1
Meas. Tech.Enzyme Inhibition Assay
pH6.4±n/a
Temperature310.15±n/a K
Ki 200±30 nM
Km121000±19000 nM
Citation Nencka, RVotruba, IHrebabecký, HJansa, PTloust'ova, EHorska, KMasojídkova, MHolý, A Discovery of 5-Substituted-6-chlorouracils as Efficient Inhibitors of Human Thymidine Phosphorylase. J Med Chem50:6016-23 (2007) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Thymidine phosphorylase
Name:Thymidine phosphorylase
Synonyms:ECGF1 | Gliostatin | PD-ECGF | Platelet-derived endothelial cell growth factor | TP | TYMP | TYPH_HUMAN | TdRPase | Thymidine Phosphorylase (TP) | Thymidine phosphorylase
Type:Enzyme
Mol. Mass.:49948.87
Organism:Homo sapiens (Human)
Description:The recombinant human thymidine phosphorylase (V79TP) was expressed in V79 Chinese hamster cells (Sigma, T-9319).
Residue:482
Sequence:
MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAA
VVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGG
VGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQA
GCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAA
VFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPP
DLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARAL
CSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVG
AELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPP
QQ
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  Blast E-value cutoff:
BDBM20061
BDBM1
NameBDBM20061
Synonyms:5-Substituted-6-chlorouracil, 7a | 6-chloro-5-(cyclopent-1-en-1-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione
TypeSmall organic molecule
Emp. Form.C9H9ClN2O2
Mol. Mass.212.633
SMILESClc1[nH]c(=O)[nH]c(=O)c1C1=CCCC1 |t:10|
Structure
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