Reaction Details |
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Target | Thymidine phosphorylase |
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Ligand | BDBM20061 |
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Substrate/Competitor | BDBM1 |
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Meas. Tech. | Enzyme Inhibition Assay |
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pH | 6.4±n/a |
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Temperature | 310.15±n/a K |
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Ki | 200±30 nM |
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Km | 121000±19000 nM |
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Citation | Nencka, R; Votruba, I; Hrebabecký, H; Jansa, P; Tloust'ova, E; Horska, K; Masojídkova, M; Holý, A Discovery of 5-Substituted-6-chlorouracils as Efficient Inhibitors of Human Thymidine Phosphorylase. J Med Chem50:6016-23 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Thymidine phosphorylase |
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Name: | Thymidine phosphorylase |
Synonyms: | ECGF1 | Gliostatin | PD-ECGF | Platelet-derived endothelial cell growth factor | TP | TYMP | TYPH_HUMAN | TdRPase | Thymidine Phosphorylase (TP) | Thymidine phosphorylase |
Type: | Enzyme |
Mol. Mass.: | 49948.87 |
Organism: | Homo sapiens (Human) |
Description: | The recombinant human thymidine phosphorylase (V79TP) was expressed in V79 Chinese hamster cells (Sigma, T-9319). |
Residue: | 482 |
Sequence: | MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAA
VVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGG
VGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQA
GCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAA
VFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPP
DLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARAL
CSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVG
AELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPP
QQ
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BDBM20061 |
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BDBM1 |
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Name | BDBM20061 |
Synonyms: | 5-Substituted-6-chlorouracil, 7a | 6-chloro-5-(cyclopent-1-en-1-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione |
Type | Small organic molecule |
Emp. Form. | C9H9ClN2O2 |
Mol. Mass. | 212.633 |
SMILES | Clc1[nH]c(=O)[nH]c(=O)c1C1=CCCC1 |t:10| |
Structure |
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