| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidine phosphorylase |
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| Ligand | BDBM20078 |
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| Substrate/Competitor | BDBM1 |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| pH | 6.4±n/a |
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| Temperature | 310.15±n/a K |
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| Ki | >20000±n/a nM |
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| Km | 121000±19000 nM |
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| Citation |  Nencka, R; Votruba, I; Hrebabecký, H; Jansa, P; Tloust'ova, E; Horska, K; Masojídkova, M; Holý, A Discovery of 5-Substituted-6-chlorouracils as Efficient Inhibitors of Human Thymidine Phosphorylase. J Med Chem50:6016-23 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Thymidine phosphorylase |
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| Name: | Thymidine phosphorylase |
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| Synonyms: | ECGF1 | Gliostatin | PD-ECGF | Platelet-derived endothelial cell growth factor | TP | TYMP | TYPH_HUMAN | TdRPase | Thymidine Phosphorylase (TP) | Thymidine phosphorylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 49948.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The recombinant human thymidine phosphorylase (V79TP) was expressed in V79 Chinese hamster cells (Sigma, T-9319). |
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| Residue: | 482 |
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| Sequence: | MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAA
VVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGG
VGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQA
GCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAA
VFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPP
DLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARAL
CSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVG
AELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPP
QQ
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| BDBM20078 |
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| BDBM1 |
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| Name | BDBM20078 |
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| Synonyms: | 6-[(2-Aminoethyl)amino]-5-phenylpyrimidine-2,4(1H,3H)-dione, 25 | 6-[(2-aminoethyl)amino]-5-phenyl-1,2,3,4-tetrahydropyrimidine-2,4-dione |
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| Type | Small organic molecule |
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| Emp. Form. | C12H14N4O2 |
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| Mol. Mass. | 246.2652 |
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| SMILES | NCCNc1[nH]c(=O)[nH]c(=O)c1-c1ccccc1 |
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| Structure | 
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