| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Transporter |
|---|
| Ligand | BDBM364427 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Norepinephrine Transporter Binding Assay |
|---|
| Ki | >100000±n/a nM |
|---|
| Citation |  Newman, AH; Okunola-Bakare, OM; Cao, J Potent and selective inhibitors of monoamine transporters; method of making; and use thereof US Patent US9862679 Publication Date 1/9/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Transporter |
|---|
| Name: | Transporter |
|---|
| Synonyms: | NE transporter | NET | Norepinephrine transporter(NET) |
|---|
| Type: | Multi-pass membrane protein |
|---|
| Mol. Mass.: | 69236.90 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | Q63380 |
|---|
| Residue: | 617 |
|---|
| Sequence: | MLLARMKPQVQPELGGADQLPEQPLRPCKTADLLVVKERNGVQCLLASQDGDAQPRETWG
KEIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQFN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHAW
NSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFA
IFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFLMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAYGITPENEHHL
VAQRDVRQFQLRHWLAI
|
|
|
|---|
| BDBM364427 |
|---|
| n/a |
|---|
| Name | BDBM364427 |
|---|
| Synonyms: | US10913711, Compound 10a | US11555013, Compound 10a | US9862679, Compound 10a |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H30N2O2S |
|---|
| Mol. Mass. | 386.551 |
|---|
| SMILES | CC(O)CN1CCN(CCS(=O)C(c2ccccc2)c2ccccc2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
