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TargetOxysterols receptor LXR-alpha
LigandBDBM20131
Substrate/Competitorbiotinylated SRC-1 peptide
Meas. Tech.Fluorescence-Resonance Energy Transfer Assay
pH7.2±n/a
Temperature310.15±n/a K
EC50 2300±n/a nM
CommentsFRET LXRalpha, efficacy = 42 %. 34% induction of ABCA1 gene activity in human THP-1 cells @ 1uM.
Citation Molteni, VLi, XNabakka, JLiang, FWityak, JKoder, AVargas, LRomeo, RMitro, NMak, PASeidel, HMHaslam, JAChow, DTuntland, TSpalding, TABrock, ABradley, MCastrillo, ATontonoz, PSaez, E N-Acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRbeta. J Med Chem50:4255-9 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Oxysterols receptor LXR-alpha
Name:Oxysterols receptor LXR-alpha
Synonyms:LXRA | Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3
Type:Enzyme Catalytic Domain
Mol. Mass.:50403.85
Organism:Homo sapiens (Human)
Description:Q13133
Residue:447
Sequence:
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA
AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG
FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK
RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM
APDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLL
ETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI
AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV
HSEQVFALRLQDKKLPPLLSEIWDVHE
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  Blast E-value cutoff:
BDBM20131
biotinylated SRC-1 peptide
Name:biotinylated SRC-1 peptide
Synonyms:n/a
Type:Peptide
Mol. Mass.:2905.78
Organism:n/a
Description:n/a
Residue:26
Sequence:
CPSSHSSLTE RHKILHRLLQ EGSPSC