Reaction Details |
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Target | Oxysterols receptor LXR-alpha |
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Ligand | BDBM20132 |
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Substrate/Competitor | BDBM19992 |
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Meas. Tech. | Scintillation Proximity Assay |
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IC50 | 5000±n/a nM |
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Citation | Molteni, V; Li, X; Nabakka, J; Liang, F; Wityak, J; Koder, A; Vargas, L; Romeo, R; Mitro, N; Mak, PA; Seidel, HM; Haslam, JA; Chow, D; Tuntland, T; Spalding, TA; Brock, A; Bradley, M; Castrillo, A; Tontonoz, P; Saez, E N-Acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRbeta. J Med Chem50:4255-9 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Oxysterols receptor LXR-alpha |
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Name: | Oxysterols receptor LXR-alpha |
Synonyms: | LXRA | Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 50403.85 |
Organism: | Homo sapiens (Human) |
Description: | Q13133 |
Residue: | 447 |
Sequence: | MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA
AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG
FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK
RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM
APDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLL
ETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI
AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV
HSEQVFALRLQDKKLPPLLSEIWDVHE
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BDBM20132 |
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BDBM19992 |
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Name | BDBM20132 |
Synonyms: | (2R)-5-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-3-[(2,4,6-trifluorophenyl)carbonyl]-2,3-dihydro-1,3,4-thiadiazole | N-Acylthiadiazoline, 3-R |
Type | Small organic molecule |
Emp. Form. | C23H16ClF3N2O3S |
Mol. Mass. | 492.898 |
SMILES | COc1cccc([C@H]2SC(=NN2C(=O)c2c(F)cc(F)cc2F)c2ccc(Cl)cc2)c1OC |r,c:9| |
Structure |
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