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TargetP2X purinoceptor 7
LigandBDBM160085
Substrate/Competitorn/a
Meas. Tech.P2X7 Radioligand Binding
Ki 1.000±n/a nM
Citation Ameriks MKRech JCSavall BMWall JL Substituted [1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulators US Patent  US10053463 Publication Date 8/21/2018
More Info.:Get all data from this article,  Assay Method
 
P2X purinoceptor 7
Name:P2X purinoceptor 7
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:68405.16
Organism:Mus musculus
Description:ChEMBL_1473824
Residue:595
Sequence:
MPACCSWNDVLQYETNKVTRIQSTNYGTVKWVLHMIVFSYISFALVSDKLYQRKEPVISS
VHTKVKGIAEVTENVTEGGVTKLGHSIFDTADYTFPLQGNSFFVMTNYVKSEGQVQTLCP
EYPRRGAQCSSDRRCKKGWMDPQSKGIQTGRCVPYDKTRKTCEVSAWCPTEEEKEAPRPA
LLRSAENFTVLIKNNIHFPGHNYTTRNILPTMNGSCTFHKTWDPQCSIFRLGDIFQEAGE
NFTEVAVQGGIMGIEIYWDCNLDSWSHHCRPRYSFRRLDDKNTDESFVPGYNFRYAKYYK
ENNVEKRTLIKAFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLLINTYSS
AFCRSGVYPYCKCCEPCTVNEYYYRKKCESIMEPKPTLKYVSFVDEPHIRMVDQQLLGKS
LQVVKGQEVPRPQMDFSDLSRLSLSLHDSPLTPGQSEEIQLLHEEVAPKSGDSPSWCQCG
NCLPSRLPEQRRALEELCCRRKPGRCITTSKLFHKLVLSRDTLQLLLLYQDPLLVLGEEA
TNSRLRHRAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKTEGQYSGFKYPY
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  Blast E-value cutoff:
BDBM160085
n/a
NameBDBM160085
Synonyms:US10047092, 26 | US10053463, 26 | US9040534, 26
TypeSmall organic molecule
Emp. Form.C18H16ClF3N6O
Mol. Mass.424.807
SMILESC[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)-c1cc(C)[nH]n1 |r|
Structure
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