Reaction Details |
| Report a problem with these data |
Target | Mitogen-activated protein kinase kinase kinase 12 |
---|
Ligand | BDBM365258 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | TR-FRET assay |
---|
Ki | 8.34±n/a nM |
---|
Citation | Cohen, F; Patel, S C-linked heterocycloaklyl substituted pyrimidines and their uses US Patent US9868720 Publication Date 1/16/2018 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Mitogen-activated protein kinase kinase kinase 12 |
---|
Name: | Mitogen-activated protein kinase kinase kinase 12 |
Synonyms: | DLK | Dual leucine zipper bearing kinase | Leucine-zipper protein kinase | M3K12_HUMAN | MAP3K12 | MAPK-upstream kinase | MUK | Mitogen-activated protein kinase kinase kinase 12 | Mixed lineage kinase | ZPK |
Type: | PROTEIN |
Mol. Mass.: | 93216.56 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1460553 |
Residue: | 859 |
Sequence: | MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGG
AAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEV
PFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVC
TQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSP
NMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVL
WELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQI
LLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELR
HALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGL
LHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRS
RRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHD
LLLRKMSSSSPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGG
AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAALLYRAAVTRSQKRGISSE
EEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNT
DERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDSDCDST
ELDNSNSVDALRPPASLPP
|
|
|
BDBM365258 |
---|
n/a |
---|
Name | BDBM365258 |
Synonyms: | (4-tert-Butyl-pyridin-2- yl)-[2-(3,3-difluoro- pyrrolidin-1-yl)-6-piperidin- 4-yl-pyrimidin-4-yl]- amine | US9868720, No. 200 |
Type | Small organic molecule |
Emp. Form. | C22H30F2N6 |
Mol. Mass. | 416.5106 |
SMILES | CC(C)(C)c1ccnc(Nc2cc(nc(n2)N2CCC(F)(F)C2)C2CCNCC2)c1 |
Structure |
|