| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase 12 |
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| Ligand | BDBM365292 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TR-FRET assay |
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| Ki | 8.75±n/a nM |
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| Citation |  Cohen, F; Patel, S C-linked heterocycloaklyl substituted pyrimidines and their uses US Patent US9868720 Publication Date 1/16/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase kinase kinase 12 |
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| Name: | Mitogen-activated protein kinase kinase kinase 12 |
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| Synonyms: | DLK | Dual leucine zipper bearing kinase | Leucine-zipper protein kinase | M3K12_HUMAN | MAP3K12 | MAPK-upstream kinase | MUK | Mitogen-activated protein kinase kinase kinase 12 | Mixed lineage kinase | ZPK |
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| Type: | PROTEIN |
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| Mol. Mass.: | 93216.56 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1460553 |
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| Residue: | 859 |
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| Sequence: | MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGG
AAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEV
PFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVC
TQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSP
NMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVL
WELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQI
LLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELR
HALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGL
LHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRS
RRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHD
LLLRKMSSSSPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGG
AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAALLYRAAVTRSQKRGISSE
EEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNT
DERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDSDCDST
ELDNSNSVDALRPPASLPP
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| BDBM365292 |
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| n/a |
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| Name | BDBM365292 |
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| Synonyms: | US9868720, No. 388 | {2-(2-Methyl-2H-pyrazol- 3-yl)-6-[1-(tetrahydro- pyran-4-ylmethyl)- pyrrolidin-3-yl]-pyrimidin- 4-yl]-(4-trifluoromethyl- pyridin-2-yl)-amine |
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| Type | Small organic molecule |
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| Emp. Form. | C24H28F3N7O |
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| Mol. Mass. | 487.5206 |
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| SMILES | Cn1nccc1-c1nc(Nc2cc(ccn2)C(F)(F)F)cc(n1)C1CCN(CC2CCOCC2)C1 |
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| Structure | 
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