| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase 12 |
|---|
| Ligand | BDBM365298 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | TR-FRET assay |
|---|
| Ki | 4.92±n/a nM |
|---|
| Citation |  Cohen, F; Patel, S C-linked heterocycloaklyl substituted pyrimidines and their uses US Patent US9868720 Publication Date 1/16/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitogen-activated protein kinase kinase kinase 12 |
|---|
| Name: | Mitogen-activated protein kinase kinase kinase 12 |
|---|
| Synonyms: | DLK | Dual leucine zipper bearing kinase | Leucine-zipper protein kinase | M3K12_HUMAN | MAP3K12 | MAPK-upstream kinase | MUK | Mitogen-activated protein kinase kinase kinase 12 | Mixed lineage kinase | ZPK |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 93216.56 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1460553 |
|---|
| Residue: | 859 |
|---|
| Sequence: | MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGG
AAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEV
PFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVC
TQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSP
NMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVL
WELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQI
LLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELR
HALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGL
LHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRS
RRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHD
LLLRKMSSSSPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGG
AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAALLYRAAVTRSQKRGISSE
EEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNT
DERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDSDCDST
ELDNSNSVDALRPPASLPP
|
|
|
|---|
| BDBM365298 |
|---|
| n/a |
|---|
| Name | BDBM365298 |
|---|
| Synonyms: | US9868720, No. 404 | {2-(3,3-Difluoro-pyrrolidin- 1-yl)-6-[1-(1H-pyrazol- 4-ylmethyl)-pyrrolidin- 3-yl]-pyrimidin-4- yl}-(4-trifluoromethyl- pyridin-2-yl)-amine |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H23F5N8 |
|---|
| Mol. Mass. | 494.4636 |
|---|
| SMILES | FC(F)(F)c1ccnc(Nc2cc(nc(n2)N2CCC(F)(F)C2)C2CCN(Cc3cn[nH]c3)C2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
