| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase 12 |
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| Ligand | BDBM365305 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TR-FRET assay |
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| Ki | 0.500±n/a nM |
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| Citation |  Cohen, F; Patel, S C-linked heterocycloaklyl substituted pyrimidines and their uses US Patent US9868720 Publication Date 1/16/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase kinase kinase 12 |
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| Name: | Mitogen-activated protein kinase kinase kinase 12 |
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| Synonyms: | DLK | Dual leucine zipper bearing kinase | Leucine-zipper protein kinase | M3K12_HUMAN | MAP3K12 | MAPK-upstream kinase | MUK | Mitogen-activated protein kinase kinase kinase 12 | Mixed lineage kinase | ZPK |
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| Type: | PROTEIN |
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| Mol. Mass.: | 93216.56 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1460553 |
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| Residue: | 859 |
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| Sequence: | MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGG
AAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEV
PFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVC
TQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSP
NMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVL
WELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQI
LLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELR
HALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGL
LHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRS
RRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHD
LLLRKMSSSSPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGG
AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAALLYRAAVTRSQKRGISSE
EEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNT
DERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDSDCDST
ELDNSNSVDALRPPASLPP
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| BDBM365305 |
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| n/a |
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| Name | BDBM365305 |
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| Synonyms: | US9868720, No. 426 | {3-[2-(3,3-Difluoro- pyrrolidin-1-yl)-6-(4-methyl- pyridin-2-ylamino)-pyrimidin- 4-yl]-piperidin- 1-yl}-(2-methoxy-4- methyl-phenyl)-methanone |
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| Type | Small organic molecule |
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| Emp. Form. | C28H32F2N6O2 |
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| Mol. Mass. | 522.5895 |
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| SMILES | COc1cc(C)ccc1C(=O)N1CCCC(C1)c1cc(Nc2cc(C)ccn2)nc(n1)N1CCC(F)(F)C1 |
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| Structure | 
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