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TargetEstrogen receptor beta
LigandBDBM20587
Substrate/Competitor17beta-estradiol (E2)
Meas. Tech.ER-alpha Radioligand Binding Assay and ERE-Luciferase Reporter Assay.
Temperature298.15±n/a K
IC50 227±n/a nM
EC50 83±n/a nM
Commentsextracted
Citation Renaud, JBischoff, SFBuhl, TFloersheim, PFournier, BHalleux, CKallen, JKeller, HSchlaeppi, JMStark, W Estrogen receptor modulators: identification and structure-activity relationships of potent ERalpha-selective tetrahydroisoquinoline ligands. J Med Chem46:2945-57 (2003) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Estrogen receptor beta
Name:Estrogen receptor beta
Synonyms:ER-beta | ESR2 | ESR2_HUMAN | ESTRB | Estradiol receptor beta (ERβ) | Estrogen receptor | Estrogen receptor (ER beta) | Estrogen receptor beta | Estrogen receptor beta (ER beta) | Estrogen receptor beta (ER) | NR3A2 | Nuclear receptor subfamily 3 group A member 2 | estrogen beta
Type:Protein
Mol. Mass.:59238.43
Organism:Homo sapiens (Human)
Description:Q92731
Residue:530
Sequence:
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPS
NVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVN
RETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH
NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH
CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTK
LADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL
VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA
DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK
CKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
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  Blast E-value cutoff:
BDBM20587
17beta-estradiol (E2)
NameBDBM20587
Synonyms:1-methyl-2-phenyl-1-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-1,2,3,4-tetrahydroisoquinolin-6-ol | tetrahydroisoquinoline derivative, 19a
TypeSmall organic molecule
Emp. Form.C28H32N2O2
Mol. Mass.428.5659
SMILESCC1(N(CCc2cc(O)ccc12)c1ccccc1)c1ccc(OCCN2CCCC2)cc1
Structure
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