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TargetMitogen-activated protein kinase 14
LigandBDBM20663
Substrate/Competitormyelin basic protein
Meas. Tech.In Vitro Enzyme Inhibition Assay and Cell-based TNFalpha Biosynthesis Inhibition Assay
pH7.5±n/a
Temperature295.15±n/a K
IC50 12±n/a nM
EC50>2000±n/a nM
Citation Hynes, JDyckman, AJLin, SWrobleski, STWu, HGillooly, KMKanner, SBLonial, HLoo, DMcIntyre, KWPitt, SShen, DRShuster, DJYang, XZhang, RBehnia, KZhang, HMarathe, PHDoweyko, AMTokarski, JSSack, JSPokross, MKiefer, SENewitt, JABarrish, JCDodd, JSchieven, GLLeftheris, K Design, synthesis, and anti-inflammatory properties of orally active 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha mitogen-activated protein kinase inhibitors. J Med Chem51:4-16 (2008) [PubMed]  Article
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Mitogen-activated protein kinase 14
Name:Mitogen-activated protein kinase 14
Synonyms:CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:Serine/threonine-protein kinase
Mol. Mass.:41286.76
Organism:Homo sapiens (Human)
Description:Q16539
Residue:360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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BDBM20663
myelin basic protein
Name:myelin basic protein
Synonyms:myelin A1 protein
Type:Other Protein Type
Mol. Mass.:4541.90
Organism:Oryctolagus cuniculus (rabbit)
Description:n/a
Residue:42
Sequence:
fgsdrgapkr gsgkdhaart thygslpqks ghrpqdenpv vh
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