| Reaction Details |
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 | Report a problem with these data |
| Target | 3-phosphoinositide-dependent protein kinase 1 [51-360] |
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| Ligand | BDBM366223 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Assay |
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| IC50 | <500±n/a nM |
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| Citation |  Lind, KE; Cao, K; Lin, EY; Nguyen, TB; Tangonan, BT; Erlanson, DA; Guckian, K; Simmons, RL; Lee, W; Sun, L; Hansen, S; Pathan, N; Zhang, L Methods of treatment using pyridinonyl PDK1 inhibitors US Patent US9873693 Publication Date 1/23/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| 3-phosphoinositide-dependent protein kinase 1 [51-360] |
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| Name: | 3-phosphoinositide-dependent protein kinase 1 [51-360] |
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| Synonyms: | 3-phosphoinositide-dependent protein kinase 1 (PDK1) | PDK1 | PDPK1 | PDPK1_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 35373.34 |
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| Organism: | Homo sapiens (Human) |
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| Description: | (aa 51-360) |
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| Residue: | 310 |
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| Sequence: | MDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAI
KILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKY
IRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVL
SPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLI
FQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENL
HQQTPPKLTA
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| BDBM366223 |
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| n/a |
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| Name | BDBM366223 |
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| Synonyms: | US9873693, Compound 146 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H18F2N6O2 |
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| Mol. Mass. | 472.4462 |
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| SMILES | Fc1ccc(Cn2cccc(C(=O)NCc3nccc(n3)-c3c[nH]c4ncccc34)c2=O)cc1F |
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| Structure | 
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