| Reaction Details |
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 | Report a problem with these data |
| Target | 3-phosphoinositide-dependent protein kinase 1 [51-360] |
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| Ligand | BDBM366092 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Assay |
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| IC50 | <500±n/a nM |
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| Citation |  Lind, KE; Cao, K; Lin, EY; Nguyen, TB; Tangonan, BT; Erlanson, DA; Guckian, K; Simmons, RL; Lee, W; Sun, L; Hansen, S; Pathan, N; Zhang, L Methods of treatment using pyridinonyl PDK1 inhibitors US Patent US9873693 Publication Date 1/23/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| 3-phosphoinositide-dependent protein kinase 1 [51-360] |
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| Name: | 3-phosphoinositide-dependent protein kinase 1 [51-360] |
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| Synonyms: | 3-phosphoinositide-dependent protein kinase 1 (PDK1) | PDK1 | PDPK1 | PDPK1_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 35373.34 |
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| Organism: | Homo sapiens (Human) |
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| Description: | (aa 51-360) |
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| Residue: | 310 |
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| Sequence: | MDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAI
KILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKY
IRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVL
SPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLI
FQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENL
HQQTPPKLTA
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| BDBM366092 |
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| n/a |
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| Name | BDBM366092 |
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| Synonyms: | US9873693, Compound 15 | US9873693, Compound 234 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H20F2N4O4S |
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| Mol. Mass. | 534.534 |
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| SMILES | OC(=O)C[C@@H](NC(=O)c1cccn(Cc2ccc(F)c(F)c2)c1=O)c1ccc(s1)-c1c[nH]c2ncccc12 |r| |
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| Structure | 
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