| Reaction Details |
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 | Report a problem with these data |
| Target | Heat shock protein HSP 90-alpha |
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| Ligand | BDBM20734 |
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| Substrate/Competitor | BDBM20732 |
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| Meas. Tech. | Hsp90 Fluorescence Polarization Binding Assay |
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| pH | 7.3±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | 60±30 nM |
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| Citation |  Gopalsamy, A; Shi, M; Golas, J; Vogan, E; Jacob, J; Johnson, M; Lee, F; Nilakantan, R; Petersen, R; Svenson, K; Chopra, R; Tam, MS; Wen, Y; Ellingboe, J; Arndt, K; Boschelli, F Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90. J Med Chem51:373-5 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Heat shock protein HSP 90-alpha |
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| Name: | Heat shock protein HSP 90-alpha |
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| Synonyms: | HS90A_HUMAN | HSP 86 | HSP86 | HSP90A | HSP90AA1 | HSPC1 | HSPCA | Heat Shock Protein 90 (Hsp90) | Heat shock 86 kDa | Heat shock protein HSP 90 (HSP90) | Heat shock protein HSP 90-alpha (HSP90) | Heat shock protein HSP 90-alpha (HSP90A) | LAP-2 | LPS-associated protein 2 | Lipopolysaccharide-associated protein 2 | Renal carcinoma antigen NY-REN-38 | heat shock protein 90kDa alpha (cytosolic), class A member 1 isoform 2 |
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| Type: | Molecular Chaperone |
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| Mol. Mass.: | 84623.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07900 |
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| Residue: | 732 |
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| Sequence: | MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIR
YESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFME
ALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPM
GRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKED
KEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRN
PDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNN
IKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKC
LELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDY
CTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKT
LVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIV
TSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVK
DLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPPLE
GDDDTSRMEEVD
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| BDBM20734 |
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| BDBM20732 |
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| Name | BDBM20734 |
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| Synonyms: | 4-chloro-6-(6-hydroxy-1,2-benzoxazol-3-yl)benzene-1,3-diol | Benzisoxazole, 15 | CHEMBL362307 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H8ClNO4 |
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| Mol. Mass. | 277.66 |
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| SMILES | Oc1ccc2c(noc2c1)-c1cc(Cl)c(O)cc1O |
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| Structure | 
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