| Reaction Details |
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 | Report a problem with these data |
| Target | Heat shock protein HSP 90-beta |
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| Ligand | BDBM20882 |
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| Substrate/Competitor | BDBM15527 |
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| Meas. Tech. | Fluorescence Polarization (FP) Assay and Cell Growth Inhibition (SRB) Assay |
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| pH | 7.4±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | 600±n/a nM |
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| EC50 | 6500±n/a nM |
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| Citation |  Brough, PA; Aherne, W; Barril, X; Borgognoni, J; Boxall, K; Cansfield, JE; Cheung, KM; Collins, I; Davies, NG; Drysdale, MJ; Dymock, B; Eccles, SA; Finch, H; Fink, A; Hayes, A; Howes, R; Hubbard, RE; James, K; Jordan, AM; Lockie, A; Martins, V; Massey, A; Matthews, TP; McDonald, E; Northfield, CJ; Pearl, LH; Prodromou, C; Ray, S; Raynaud, FI; Roughley, SD; Sharp, SY; Surgenor, A; Walmsley, DL; Webb, P; Wood, M; Workman, P; Wright, L 4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer. J Med Chem51:196-218 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Heat shock protein HSP 90-beta |
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| Name: | Heat shock protein HSP 90-beta |
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| Synonyms: | HS90B_HUMAN | HSP 84 | HSP 90 | HSP90AB1 | HSP90B | HSPC2 | HSPCB | Heat Shock Protein 90 (Hsp90) | Heat shock protein HSP 90 (Hsp90) |
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| Type: | Molecular Chaperone |
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| Mol. Mass.: | 83229.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08238 |
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| Residue: | 724 |
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| Sequence: | MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT
DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG
ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE
DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE
YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA
EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ
KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG
LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA
NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE
TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM
EEVD
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| BDBM20882 |
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| BDBM15527 |
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| Name | BDBM20882 |
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| Synonyms: | 4-[4-(4-benzylpiperazin-1-yl)-1H-pyrazol-3-yl]-6-chlorobenzene-1,3-diol | CHEMBL251974 | Piperazine, 8 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21ClN4O2 |
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| Mol. Mass. | 384.859 |
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| SMILES | Oc1cc(O)c(cc1Cl)-c1n[nH]cc1N1CCN(Cc2ccccc2)CC1 |
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| Structure | 
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