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TargetHeat shock protein HSP 90-beta
LigandBDBM20901
Substrate/CompetitorBDBM15527
Meas. Tech.Fluorescence Polarization (FP) Assay and Cell Growth Inhibition (SRB) Assay
pH7.4±n/a
Temperature295.15±n/a K
IC50 14±n/a nM
EC50 1980±n/a nM
Citation Brough, PAAherne, WBarril, XBorgognoni, JBoxall, KCansfield, JECheung, KMCollins, IDavies, NGDrysdale, MJDymock, BEccles, SAFinch, HFink, AHayes, AHowes, RHubbard, REJames, KJordan, AMLockie, AMartins, VMassey, AMatthews, TPMcDonald, ENorthfield, CJPearl, LHProdromou, CRay, SRaynaud, FIRoughley, SDSharp, SYSurgenor, AWalmsley, DLWebb, PWood, MWorkman, PWright, L 4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer. J Med Chem51:196-218 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Heat shock protein HSP 90-beta
Name:Heat shock protein HSP 90-beta
Synonyms:HS90B_HUMAN | HSP 84 | HSP 90 | HSP90AB1 | HSP90B | HSPC2 | HSPCB | Heat Shock Protein 90 (Hsp90) | Heat shock protein HSP 90 (Hsp90)
Type:Molecular Chaperone
Mol. Mass.:83229.45
Organism:Homo sapiens (Human)
Description:P08238
Residue:724
Sequence:
MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT
DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG
ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE
DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE
YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA
EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ
KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG
LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA
NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE
TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM
EEVD
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BDBM20901
BDBM15527
NameBDBM20901
Synonyms:5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-{[(2-methanesulfonylethyl)amino]methyl}phenyl)-1,2-oxazole-3-carboxamide | Isoxazole, 30b | US10413550, Example 37 | US11234987, Example 37 | US9718793, 37
TypeSmall organic molecule
Emp. Form.C22H24ClN3O6S
Mol. Mass.493.96
SMILESCCNC(=O)c1noc(c1-c1ccc(CNCCS(C)(=O)=O)cc1)-c1cc(Cl)c(O)cc1O
Structure
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