| Reaction Details |
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 | Report a problem with these data |
| Target | Heat shock protein HSP 90-beta |
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| Ligand | BDBM20910 |
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| Substrate/Competitor | BDBM15527 |
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| Meas. Tech. | Fluorescence Polarization (FP) Assay and Cell Growth Inhibition (SRB) Assay |
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| IC50 | 343±n/a nM |
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| EC50 | 2780±n/a nM |
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| Citation |  Brough, PA; Aherne, W; Barril, X; Borgognoni, J; Boxall, K; Cansfield, JE; Cheung, KM; Collins, I; Davies, NG; Drysdale, MJ; Dymock, B; Eccles, SA; Finch, H; Fink, A; Hayes, A; Howes, R; Hubbard, RE; James, K; Jordan, AM; Lockie, A; Martins, V; Massey, A; Matthews, TP; McDonald, E; Northfield, CJ; Pearl, LH; Prodromou, C; Ray, S; Raynaud, FI; Roughley, SD; Sharp, SY; Surgenor, A; Walmsley, DL; Webb, P; Wood, M; Workman, P; Wright, L 4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer. J Med Chem51:196-218 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Heat shock protein HSP 90-beta |
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| Name: | Heat shock protein HSP 90-beta |
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| Synonyms: | HS90B_HUMAN | HSP 84 | HSP 90 | HSP90AB1 | HSP90B | HSPC2 | HSPCB | Heat Shock Protein 90 (Hsp90) | Heat shock protein HSP 90 (Hsp90) |
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| Type: | Molecular Chaperone |
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| Mol. Mass.: | 83229.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08238 |
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| Residue: | 724 |
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| Sequence: | MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT
DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG
ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE
DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE
YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA
EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ
KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG
LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA
NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE
TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM
EEVD
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| BDBM20910 |
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| BDBM15527 |
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| Name | BDBM20910 |
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| Synonyms: | 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-{3-[(4-methylpiperazin-1-yl)methyl]phenyl}-1,2-oxazole-3-carboxamide | Isoxazole, 31b | US10413550, Example 48 | US11234987, Example 48 | US9718793, 48 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H27ClN4O4 |
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| Mol. Mass. | 470.949 |
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| SMILES | CCNC(=O)c1noc(c1-c1cccc(CN2CCN(C)CC2)c1)-c1cc(Cl)c(O)cc1O |
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| Structure | 
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