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TargetCorticotropin-releasing factor receptor 1
LigandBDBM20966
Substrate/Competitor125I-Tyr(0)-ovine-CRF
Meas. Tech.Receptor Binding Assay
pH7±n/a
Temperature295.15±n/a K
IC50 5.1±n/a nM
Citation Chen, YL; Obach, RS; Braselton, J; Corman, ML; Forman, J; Freeman, J; Gallaschun, RJ; Mansbach, R; Schmidt, AW; Sprouse, JS; Tingley Iii, FD; Winston, E; Schulz, DW 2-Aryloxy-4-alkylaminopyridines: Discovery of Novel Corticotropin-Releasing Factor 1 Antagonists. J Med Chem51:1385-92 (2008) [PubMed]  Article
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Corticotropin-releasing factor receptor 1
Name:Corticotropin-releasing factor receptor 1
Synonyms:CRF-R | CRF1 | CRFR1_RAT | CRH-R 1 | Corticotropin releasing factor receptor | Corticotropin releasing factor receptor 1 | Corticotropin-releasing Factor Receptor 1 | Corticotropin-releasing hormone receptor 1 | Crhr | Crhr1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:47870.75
Organism:Rattus norvegicus (rat)
Description:Receptor binding assays were performed using rat cortex homogenate.
Residue:415
Sequence:
MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEV
HQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPF
PIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA
STTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVS
VFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
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BDBM20966
125I-Tyr(0)-ovine-CRF
Name:125I-Tyr(0)-ovine-CRF
Synonyms:Ovine Tyr-CRF | oCRF
Type:radiolabeled substrate
Mol. Mass.:4833.46
Organism:Ovis aries (sheep)
Description:n/a
Residue:42
Sequence:
YSQE PPISLDLTFH LLREVLEMTK ADQLAQQAHS NRKLLDIA
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