| Reaction Details |
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 | Report a problem with these data |
| Target | Macrophage colony-stimulating factor 1 receptor |
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| Ligand | BDBM21103 |
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| Substrate/Competitor | biotinylated peptide substrate |
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| Meas. Tech. | HTRF Assay of Receptor Tyrosine Kinase |
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| IC50 | 27±n/a nM |
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| Citation |  Ji, Z; Ahmed, AA; Albert, DH; Bouska, JJ; Bousquet, PF; Cunha, GA; Diaz, G; Glaser, KB; Guo, J; Harris, CM; Li, J; Marcotte, PA; Moskey, MD; Oie, T; Pease, L; Soni, NB; Stewart, KD; Davidsen, SK; Michaelides, MR 3-Amino-benzo[d]isoxazoles as Novel Multitargeted Inhibitors of Receptor Tyrosine Kinases. J Med Chem51:1231-41 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Macrophage colony-stimulating factor 1 receptor |
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| Name: | Macrophage colony-stimulating factor 1 receptor |
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| Synonyms: | CSF1R | CSF1R_HUMAN | FMS | Fms proto-oncogene | Macrophage colony stimulating factor receptor | Macrophage colony-stimulating factor 1 receptor (FMS) | Macrophage colony-stimulating factor 1 receptor (c-FMS) | Macrophage colony-stimulating factor 1 receptor (cFMS) | Proto-oncogene c-Fms | Tyrosine Kinase CSF1-R | c-fms | cFMS |
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| Type: | Protein |
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| Mol. Mass.: | 107979.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07333 |
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| Residue: | 972 |
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| Sequence: | MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTL
YSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFED
QDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSAL
MGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHN
NTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAY
LNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTY
RHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCA
ASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHN
QTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKY
KQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEAT
AFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVL
VITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGV
DTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVA
ARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWS
YGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHR
PTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIA
QPLLQPNNYQFC
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| BDBM21103 |
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| biotinylated peptide substrate |
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| Name: | biotinylated peptide substrate |
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| Synonyms: | n/a |
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| Type: | Peptide |
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| Mol. Mass.: | 2470.20 |
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| Organism: | n/a |
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| Description: | n/a |
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| Residue: | 21 |
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| Sequence: | Biotin-Ahx-AEEEYFFLFA-amide
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