| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase MARK2 |
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| Ligand | BDBM247039 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PAR-1 FLIPR Assay |
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| IC50 | 4.43±n/a nM |
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| Citation |  Yang, Z; Zhang, F; Dong, G; Knowles, SL; Maletic, M Preparation and use of 7a-amide substituted- 6,6-difluoro bicyclic himbacine derivatives as PAR-1 receptor antagonists US Patent US9701669 Publication Date 7/11/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase MARK2 |
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| Name: | Serine/threonine-protein kinase MARK2 |
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| Synonyms: | ELKL motif kinase 1 | EMK1 | MAP/microtubule affinity-regulating kinase 2 | MARK2 | MARK2_HUMAN | PAR1 homolog | Par-1 | Serine/threonine-protein kinase MARK2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 87953.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774586 |
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| Residue: | 788 |
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| Sequence: | MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG
KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE
TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN
LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL
YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK
DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL
LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS
NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST
NRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHP
NKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAG
QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPE
SKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDA
NSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIAS
KIANELKL
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| BDBM247039 |
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| n/a |
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| Name | BDBM247039 |
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| Synonyms: | 2-((1R,3aR, 6S,7R,7aS)-7- ((E)-2-(5-(2- cyanophenyl) pyridin-2- yl)vinyl)-5,5- difluoro- 1,6-dimethyl-3- oxooctahydro- isobenzofuran- 3a- yl)propanamide | US9701669, 7 | US9701669, 8 | US9701669, 9 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H27F2N3O3 |
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| Mol. Mass. | 479.5184 |
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| SMILES | CC(C(N)=O)[C@@]12CC(F)(F)[C@@H](C)[C@H](\C=C\c3ccc(cn3)-c3ccccc3C#N)[C@@H]1[C@@H](C)OC2=O |r| |
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| Structure | 
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