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TargetNuclear receptor ROR-gamma
LigandBDBM368656
Substrate/Competitorn/a
Meas. Tech.Assay of Co-Activator Recruitment by TR-FRET
IC50 2.10±n/a nM
Citation Schnute MEFlick ACJones PKaila NMente SRTrzupek JDVazquez MLWennerstal GMXing LZamaratski EZhang LUnwalla RJ Methyl- and trifluoromethyl-substituted pyrrolopyridine modulators of RORC2 and methods of use therof US Patent  US10227346 Publication Date 3/12/2019  Article
More Info.:Get all data from this article,  Assay Method
 
Nuclear receptor ROR-gamma
Name:Nuclear receptor ROR-gamma
Synonyms:NR1F3 | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:Protein
Mol. Mass.:58218.40
Organism:Homo sapiens (Human)
Description:P51449
Residue:518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
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  Blast E-value cutoff:
BDBM368656
n/a
NameBDBM368656
Synonyms:3-cyano-N-(3-((1R,5S,8r)-3-isobutyryl-3- azabicyclo[3.2.1]octan-8-yl)-1-methyl-4- (trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-4- methoxybenzamide. | US10227346, Example 78 | US9920054, Example 78
TypeSmall organic molecule
Emp. Form.C29H30F3N5O3
Mol. Mass.553.5754
SMILESCOc1ccc(cc1C#N)C(=O)Nc1cnc2n(C)cc(C3[C@H]4CC[C@@H]3CN(C4)C(=O)C(C)C)c2c1C(F)(F)F |r|
Structure
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