Reaction Details |
| Report a problem with these data |
Target | Serine/threonine-protein kinase/endoribonuclease IRE1 |
---|
Ligand | BDBM160350 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | IRE-1alpha Assay |
---|
pH | 7.5±n/a |
---|
Temperature | 303.15±n/a K |
---|
IC50 | <1000±n/a nM |
---|
EC50 | <10000±n/a nM |
---|
Comments | extracted |
---|
Citation | Zeng, Q; Toro, A; Patterson, JB; Wade, WS; Zubovics, Z; Yang, Y; Wu, Z IRE-1α inhibitors US Patent US9693992 Publication Date 7/4/2017 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Serine/threonine-protein kinase/endoribonuclease IRE1 |
---|
Name: | Serine/threonine-protein kinase/endoribonuclease IRE1 |
Synonyms: | ERN1 | ERN1_HUMAN | Endoplasmic reticulum-to-nucleus signaling 1 | Endoribonuclease | IRE1 | IRE1a | Inositol requiring enzyme 1 (IRE-1alpha) | Inositol-requiring enzyme 1 (IRE1a) | Inositol-requiring protein 1 | Inositol-requiring protein 1 (IRE1a) | Ire1-alpha | Serine/threonine-protein kinase | Serine/threonine-protein kinase/endoribonuclease IRE1 | Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha | hIRE1p |
Type: | Enzyme |
Mol. Mass.: | 109731.20 |
Organism: | Homo sapiens (Human) |
Description: | O75460 |
Residue: | 977 |
Sequence: | MPARRLLLLLTLLLPGLGIFGSTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDP
VLQVPTHVEEPAFLPDPNDGSLYTLGSKNNEGLTKLPFTIPELVQASPCRSSDGILYMGK
KQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYF
DYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLRKV
MHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMV
HEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDVKFDPGLKSKNKLNYLRNYWL
LIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSFEEVINLVDQTSENAPTTVSR
DVEEKPAHAPARPEAPVDSMLKDMATIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQ
KELEKIQLLQQQQQQLPFHPPGDTAQDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSG
SSASKAGSSPSLEQDDGDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKR
ILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAH
LGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAV
GRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQ
RQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQ
FFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDL
LRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPY
YFHEPPEPQPPVTPDAL
|
|
|
BDBM160350 |
---|
n/a |
---|
Name | BDBM160350 |
Synonyms: | US9040714, 18 | US9693992, 18 |
Type | Small organic molecule |
Emp. Form. | C22H19NO5 |
Mol. Mass. | 377.39 |
SMILES | Cc1c(-c2ccc(cc2)C(=O)N2CCCC2)c(=O)oc2c(C=O)c(O)ccc12 |
Structure |
|