| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
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| Ligand | BDBM253626 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | MGAT LCMS Assay |
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| pH | 7.4±n/a |
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| IC50 | 1.40±n/a nM |
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| Comments | extracted |
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| Citation |  Meng, W; Zhao, G Dihydropyridinone MGAT2 inhibitors for use in the treatment of metabolic disorders US Patent US9701672 Publication Date 7/11/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
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| Name: | Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
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| Synonyms: | 2.4.1.143 | Beta-1,2-N-acetylglucosaminyltransferase II | GNT-II | GlcNAc-T II | MGAT2 | MGAT2_HUMAN | Mannoside acetylglucosaminyltransferase 2 | Monoacylglycerol acyltransferase 2 (MGAT2) | Monoacylglycerol acyltransferase type 2 (h-MGAT2) | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II | h-MGAT2 (human monoacylglycerol acyltransferase type 2) |
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| Type: | n/a |
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| Mol. Mass.: | 51567.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q10469 |
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| Residue: | 447 |
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| Sequence: | MRFRIYKRKVLILTLVVAACGFVLWSSNGRQRKNEALAPPLLDAEPARGAGGRGGDHPSV
AVGIRRVSNVSAASLVPAVPQPEADNLTLRYRSLVYQLNFDQTLRNVDKAGTWAPRELVL
VVQVHNRPEYLRLLLDSLRKAQGIDNVLVIFSHDFWSTEINQLIAGVNFCPVLQVFFPFS
IQLYPNEFPGSDPRDCPRDLPKNAALKLGCINAEYPDSFGHYREAKFSQTKHHWWWKLHF
VWERVKILRDYAGLILFLEEDHYLAPDFYHVFKKMWKLKQQECPECDVLSLGTYSASRSF
YGMADKVDVKTWKSTEHNMGLALTRNAYQKLIECTDTFCTYDDYNWDWTLQYLTVSCLPK
FWKVLVPQIPRIFHAGDCGMHHKKTCRPSTQSAQIESLLNNNKQYMFPETLTISEKFTVV
AISPPRKNGGWGDIRDHELCKSYRRLQ
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| BDBM253626 |
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| n/a |
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| Name | BDBM253626 |
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| Synonyms: | US9701672, 57 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H23F6N5O3S |
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| Mol. Mass. | 587.537 |
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| SMILES | COc1cc(OCCCC(F)(F)F)ccc1[C@@]1(CC(c2ccc(s2)C2CC2)=C(c2nnn[nH]2)C(=O)N1)C(F)(F)F |r,t:29| |
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| Structure | 
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