| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
|---|
| Ligand | BDBM253631 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | MGAT LCMS Assay |
|---|
| pH | 7.4±n/a |
|---|
| IC50 | 2.10±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Meng, W; Zhao, G Dihydropyridinone MGAT2 inhibitors for use in the treatment of metabolic disorders US Patent US9701672 Publication Date 7/11/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
|---|
| Name: | Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
|---|
| Synonyms: | 2.4.1.143 | Beta-1,2-N-acetylglucosaminyltransferase II | GNT-II | GlcNAc-T II | MGAT2 | MGAT2_HUMAN | Mannoside acetylglucosaminyltransferase 2 | Monoacylglycerol acyltransferase 2 (MGAT2) | Monoacylglycerol acyltransferase type 2 (h-MGAT2) | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II | h-MGAT2 (human monoacylglycerol acyltransferase type 2) |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 51567.80 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q10469 |
|---|
| Residue: | 447 |
|---|
| Sequence: | MRFRIYKRKVLILTLVVAACGFVLWSSNGRQRKNEALAPPLLDAEPARGAGGRGGDHPSV
AVGIRRVSNVSAASLVPAVPQPEADNLTLRYRSLVYQLNFDQTLRNVDKAGTWAPRELVL
VVQVHNRPEYLRLLLDSLRKAQGIDNVLVIFSHDFWSTEINQLIAGVNFCPVLQVFFPFS
IQLYPNEFPGSDPRDCPRDLPKNAALKLGCINAEYPDSFGHYREAKFSQTKHHWWWKLHF
VWERVKILRDYAGLILFLEEDHYLAPDFYHVFKKMWKLKQQECPECDVLSLGTYSASRSF
YGMADKVDVKTWKSTEHNMGLALTRNAYQKLIECTDTFCTYDDYNWDWTLQYLTVSCLPK
FWKVLVPQIPRIFHAGDCGMHHKKTCRPSTQSAQIESLLNNNKQYMFPETLTISEKFTVV
AISPPRKNGGWGDIRDHELCKSYRRLQ
|
|
|
|---|
| BDBM253631 |
|---|
| n/a |
|---|
| Name | BDBM253631 |
|---|
| Synonyms: | US9701672, 62 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H19F7N6O2S |
|---|
| Mol. Mass. | 564.479 |
|---|
| SMILES | CCc1cnc(s1)C1=C(c2nnn[nH]2)C(=O)N[C@@](C1)(c1ccc(OCCCC(F)(F)F)cc1F)C(F)(F)F |r,c:8| |
|---|
| Structure | 
|
|---|
Search and Browse
