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TargetCarboxypeptidase A1
LigandBDBM21464
Substrate/CompetitorBDBM21477
Meas. Tech.Enzyme Inhibition Assay
Ki 0.5±n/a nM
Citation Mores, AMatziari, MBeau, FCuniasse, PYiotakis, ADive, V Development of Potent and Selective Phosphinic Peptide Inhibitors of Angiotensin-Converting Enzyme 2. J Med Chem51:2216-2226 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Carboxypeptidase A1
Name:Carboxypeptidase A1
Synonyms:CBPA1_BOVIN | CPA | CPA1 | Carboxypeptidase A | Carboxypeptidase A (CPA) | Carboxypeptidase A1 precursor
Type:Enzyme
Mol. Mass.:47073.90
Organism:Bos taurus (bovine)
Description:From Sigma-Aldrich Co.
Residue:419
Sequence:
MQGLLILSVLLGAALGKEDFVGHQVLRITAADEAEVQTVKELEDLEHLQLDFWRGPGQPG
SPIDVRVPFPSLQAVKVFLEAHGIRYRIMIEDVQSLLDEEQEQMFASQSRARSTNTFNYA
TYHTLDEIYDFMDLLVAEHPQLVSKLQIGRSYEGRPIYVLKFSTGGSNRPAIWIDLGIHS
REWITQATGVWFAKKFTEDYGQDPSFTAILDSMDIFLEIVTNPDGFAFTHSQNRLWRKTR
SVTSSSLCVGVDANRNWDAGFGKAGASSSPCSETYHGKYANSEVEVKSIVDFVKDHGNFK
AFLSIHSYSQLLLYPYGYTTQSIPDKTELNQVAKSAVEALKSLYGTSYKYGSIITTIYQA
SGGSIDWSYNQGIKYSFTFELRDTGRYGFLLPASQIIPTAQETWLGVLTIMEHTLNNLY
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  Blast E-value cutoff:
BDBM21464
BDBM21477
NameBDBM21464
Synonyms:2-benzyl-3-{[1-(2-acetamido-4-methylpentanoyl)pyrrolidin-2-yl](hydroxy)phosphoryl}propanoic acid | Phosphinic Peptide Inhibitor, 28 FII | The second fraction of the HPLC chromatogram.
TypeSmall organic molecule
Emp. Form.C22H33N2O6P
Mol. Mass.452.481
SMILESCC(C)CC(NC(C)=O)C(=O)N1CCC=C1P(O)(O)CC(Cc1ccccc1)C(O)=O |c:14|
Structure
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