| Reaction Details |
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 | Report a problem with these data |
| Target | Carboxypeptidase A1 |
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| Ligand | BDBM21471 |
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| Substrate/Competitor | BDBM21477 |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| Ki | 0.3±n/a nM |
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| Citation |  Mores, A; Matziari, M; Beau, F; Cuniasse, P; Yiotakis, A; Dive, V Development of Potent and Selective Phosphinic Peptide Inhibitors of Angiotensin-Converting Enzyme 2. J Med Chem51:2216-2226 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Carboxypeptidase A1 |
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| Name: | Carboxypeptidase A1 |
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| Synonyms: | CBPA1_BOVIN | CPA | CPA1 | Carboxypeptidase A | Carboxypeptidase A (CPA) | Carboxypeptidase A1 precursor |
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| Type: | Enzyme |
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| Mol. Mass.: | 47073.90 |
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| Organism: | Bos taurus (bovine) |
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| Description: | From Sigma-Aldrich Co. |
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| Residue: | 419 |
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| Sequence: | MQGLLILSVLLGAALGKEDFVGHQVLRITAADEAEVQTVKELEDLEHLQLDFWRGPGQPG
SPIDVRVPFPSLQAVKVFLEAHGIRYRIMIEDVQSLLDEEQEQMFASQSRARSTNTFNYA
TYHTLDEIYDFMDLLVAEHPQLVSKLQIGRSYEGRPIYVLKFSTGGSNRPAIWIDLGIHS
REWITQATGVWFAKKFTEDYGQDPSFTAILDSMDIFLEIVTNPDGFAFTHSQNRLWRKTR
SVTSSSLCVGVDANRNWDAGFGKAGASSSPCSETYHGKYANSEVEVKSIVDFVKDHGNFK
AFLSIHSYSQLLLYPYGYTTQSIPDKTELNQVAKSAVEALKSLYGTSYKYGSIITTIYQA
SGGSIDWSYNQGIKYSFTFELRDTGRYGFLLPASQIIPTAQETWLGVLTIMEHTLNNLY
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| BDBM21471 |
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| BDBM21477 |
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| Name | BDBM21471 |
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| Synonyms: | 2-benzyl-3-{[1-(2-acetamido-4-methylpentanamido)-2-phenylethyl](hydroxy)phosphoryl}propanoic acid | Phosphinic Peptide Inhibitor, 35 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H35N2O6P |
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| Mol. Mass. | 502.5397 |
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| SMILES | CC(C)CC(NC(C)=O)C(=O)NC(Cc1ccccc1)P(O)(=O)CC(Cc1ccccc1)C(O)=O |
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| Structure | 
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