Reaction Details |
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Target | Carboxypeptidase A1 |
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Ligand | BDBM21491 |
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Substrate/Competitor | BDBM21477 |
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Meas. Tech. | CPA Inhibition Assay |
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pH | 7.5±n/a |
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Temperature | 295.15±n/a K |
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IC50 | 12000±n/a nM |
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Citation | Dales, NA; Gould, AE; Brown, JA; Calderwood, EF; Guan, B; Minor, CA; Gavin, JM; Hales, P; Kaushik, VK; Stewart, M; Tummino, PJ; Vickers, CS; Ocain, TD; Patane, MA Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors. J Am Chem Soc124:11852-3 (2002) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Carboxypeptidase A1 |
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Name: | Carboxypeptidase A1 |
Synonyms: | CBPA1_BOVIN | CPA | CPA1 | Carboxypeptidase A | Carboxypeptidase A (CPA) | Carboxypeptidase A1 precursor |
Type: | Enzyme |
Mol. Mass.: | 47073.90 |
Organism: | Bos taurus (bovine) |
Description: | From Sigma-Aldrich Co. |
Residue: | 419 |
Sequence: | MQGLLILSVLLGAALGKEDFVGHQVLRITAADEAEVQTVKELEDLEHLQLDFWRGPGQPG
SPIDVRVPFPSLQAVKVFLEAHGIRYRIMIEDVQSLLDEEQEQMFASQSRARSTNTFNYA
TYHTLDEIYDFMDLLVAEHPQLVSKLQIGRSYEGRPIYVLKFSTGGSNRPAIWIDLGIHS
REWITQATGVWFAKKFTEDYGQDPSFTAILDSMDIFLEIVTNPDGFAFTHSQNRLWRKTR
SVTSSSLCVGVDANRNWDAGFGKAGASSSPCSETYHGKYANSEVEVKSIVDFVKDHGNFK
AFLSIHSYSQLLLYPYGYTTQSIPDKTELNQVAKSAVEALKSLYGTSYKYGSIITTIYQA
SGGSIDWSYNQGIKYSFTFELRDTGRYGFLLPASQIIPTAQETWLGVLTIMEHTLNNLY
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BDBM21491 |
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BDBM21477 |
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Name | BDBM21491 |
Synonyms: | (2S)-2-{[(1S)-1-carboxy-2-[1-(2-cyclohexylpropan-2-yl)-1H-imidazol-5-yl]ethyl]amino}-4-methylpentanoic acid | Amino dicarboxylate analogue, 7 |
Type | Small organic molecule |
Emp. Form. | C21H35N3O4 |
Mol. Mass. | 393.5203 |
SMILES | CC(C)C[C@H](N[C@@H](Cc1cncn1C(C)(C)C1CCCCC1)C(O)=O)C(O)=O |r| |
Structure |
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