Reaction Details |
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Target | Prostaglandin D2 receptor 2 |
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Ligand | BDBM21586 |
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Substrate/Competitor | BDBM21544 |
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Meas. Tech. | Radioligand Binding Assay and [35S] GTP-gamma-S Binding Assay |
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Ki | 55±n/a nM |
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Citation | Crosignani, S; Page, P; Missotten, M; Colovray, V; Cleva, C; Arrighi, JF; Atherall, J; Macritchie, J; Martin, T; Humbert, Y; Gaudet, M; Pupowicz, D; Maio, M; Pittet, PA; Golzio, L; Giachetti, C; Rocha, C; Bernardinelli, G; Filinchuk, Y; Scheer, A; Schwarz, MK; Chollet, A Discovery of a New Class of Potent, Selective, and Orally Bioavailable CRTH2 (DP2) Receptor Antagonists for the Treatment of Allergic Inflammatory Diseases. J Med Chem51:2227-2243 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Prostaglandin D2 receptor 2 |
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Name: | Prostaglandin D2 receptor 2 |
Synonyms: | CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2) |
Type: | Enzyme |
Mol. Mass.: | 43295.45 |
Organism: | Homo sapiens (Human) |
Description: | Q9Y5Y4 |
Residue: | 395 |
Sequence: | MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
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BDBM21586 |
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BDBM21544 |
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Name | BDBM21586 |
Synonyms: | 2-(5-chloro-1'-{[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-2,2',5'-trione)acetic acid | Spiro-indolinone analogue, 78 |
Type | Small organic molecule |
Emp. Form. | C23H15Cl2N3O5S |
Mol. Mass. | 516.353 |
SMILES | OC(=O)CN1C(=O)C2(CC(=O)N(Cc3csc(n3)-c3ccc(Cl)cc3)C2=O)c2cc(Cl)ccc12 |
Structure |
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