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TargetProstaglandin D2 receptor 2
LigandBDBM21598
Substrate/CompetitorBDBM21544
Meas. Tech.Radioligand Binding Assay and [35S] GTP-gamma-S Binding Assay
Ki 32±n/a nM
Citation Crosignani, SPage, PMissotten, MColovray, VCleva, CArrighi, JFAtherall, JMacritchie, JMartin, THumbert, YGaudet, MPupowicz, DMaio, MPittet, PAGolzio, LGiachetti, CRocha, CBernardinelli, GFilinchuk, YScheer, ASchwarz, MKChollet, A Discovery of a New Class of Potent, Selective, and Orally Bioavailable CRTH2 (DP2) Receptor Antagonists for the Treatment of Allergic Inflammatory Diseases. J Med Chem51:2227-2243 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Prostaglandin D2 receptor 2
Name:Prostaglandin D2 receptor 2
Synonyms:CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2)
Type:Enzyme
Mol. Mass.:43295.45
Organism:Homo sapiens (Human)
Description:Q9Y5Y4
Residue:395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
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  Blast E-value cutoff:
BDBM21598
BDBM21544
NameBDBM21598
Synonyms:2-{5-chloro-1'-[(5-chloro-2-fluorophenyl)methyl]-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-2,5'-dione}acetic acid | Spiro-indolinone analogue, 90
TypeSmall organic molecule
Emp. Form.C20H15Cl2FN2O4
Mol. Mass.437.249
SMILESOC(=O)CN1C(=O)C2(CN(Cc3cc(Cl)ccc3F)C(=O)C2)c2cc(Cl)ccc12
Structure
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