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TargetG protein-coupled receptor 44
LigandBDBM21599
Substrate/CompetitorBDBM21544
Meas. Tech.Radioligand Binding Assay
Ki 3.8±n/a nM
EC50 19±n/a nM
Citation Crosignani SPage PMissotten MColovray VCleva CArrighi JFAtherall JMacritchie JMartin THumbert YGaudet MPupowicz DMaio MPittet PAGolzio LGiachetti CRocha CBernardinelli GFilinchuk YScheer ASchwarz MKChollet A Discovery of a New Class of Potent, Selective, and Orally Bioavailable CRTH2 (DP2) Receptor Antagonists for the Treatment of Allergic Inflammatory Diseases. J Med Chem 51:2227-2243 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
G protein-coupled receptor 44
Name:G protein-coupled receptor 44
Synonyms:CD_antigen=CD294 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | G-protein coupled receptor 44 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2)
Type:Enzyme
Mol. Mass.:43295.45
Organism:Homo sapiens (Human)
Description:Q9Y5Y4
Residue:395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
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  Blast E-value cutoff:
BDBM21599
BDBM21544
NameBDBM21599
Synonyms:2-{5-chloro-1'-[(3-methyl-5-phenyl-1,2-oxazol-4-yl)methyl]-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-2,5'-dione}acetic acid | Spiro-indolinone analogue, 91
TypeSmall organic molecule
Emp. Form.C24H20ClN3O5
Mol. Mass.465.886
SMILESCc1noc(c1CN1CC2(CC1=O)C(=O)N(CC(O)=O)c1ccc(Cl)cc21)-c1ccccc1
Structure
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