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TargetProstaglandin D Synthase
LigandBDBM21613
Substrate/CompetitorBDBM21614
Meas. Tech.In Vitro GST Activity Assay
pH7.2±n/a
Temperature295.15±n/a K
IC50 11600±n/a nM
Citation Hohwy MSpadola LLundquist BHawtin PDahmén JGroth-Clausen INilsson EPersdotter Svon Wachenfeldt KFolmer RHEdman K Novel prostaglandin d synthase inhibitors generated by fragment-based drug design. J Med Chem 51:2178-86 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Prostaglandin D Synthase
Name:Prostaglandin D Synthase
Synonyms:Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | Prostaglandin D
Type:Enzyme
Mol. Mass.:23341.07
Organism:Homo sapiens (Human)
Description:The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag.
Residue:199
Sequence:
MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLT
LHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELL
TYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKK
VQAIPAVANWIKRRPQTKL
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  Blast E-value cutoff:
BDBM21613
BDBM21614
NameBDBM21613
Synonyms:2-[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enamido]benzoic acid | N-(3 ,4 -dimethoxycinnamoyl)anthranilic acid | Rizaben | Tranilast
TypeSmall organic molecule
Emp. Form.C18H17NO5
Mol. Mass.327.3313
SMILESCOc1ccc(\C=C\C(=O)Nc2ccccc2C(O)=O)cc1OC
Structure
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