Reaction Details |
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Target | Hematopoietic prostaglandin D synthase |
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Ligand | BDBM21615 |
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Substrate/Competitor | BDBM21614 |
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Meas. Tech. | In Vitro GST Activity Assay |
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pH | 7.2±n/a |
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Temperature | 295.15±n/a K |
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IC50 | 890000±n/a nM |
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Citation | Hohwy, M; Spadola, L; Lundquist, B; Hawtin, P; Dahmén, J; Groth-Clausen, I; Nilsson, E; Persdotter, S; von Wachenfeldt, K; Folmer, RH; Edman, K Novel prostaglandin d synthase inhibitors generated by fragment-based drug design. J Med Chem51:2178-86 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Hematopoietic prostaglandin D synthase |
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Name: | Hematopoietic prostaglandin D synthase |
Synonyms: | GSTS | Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | HPGDS | HPGDS_HUMAN | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | PTGDS2 | Prostaglandin D | Prostaglandin D Synthase |
Type: | Enzyme |
Mol. Mass.: | 23341.07 |
Organism: | Homo sapiens (Human) |
Description: | The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag. |
Residue: | 199 |
Sequence: | MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLT
LHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELL
TYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKK
VQAIPAVANWIKRRPQTKL
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BDBM21615 |
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BDBM21614 |
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Name | BDBM21615 |
Synonyms: | 1-phenyl-1H-pyrazole-4-carboxylic acid | Pyrazole, 1 |
Type | Small organic molecule |
Emp. Form. | C10H8N2O2 |
Mol. Mass. | 188.1827 |
SMILES | OC(=O)c1cnn(c1)-c1ccccc1 |
Structure |
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