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TargetHematopoietic prostaglandin D synthase
LigandBDBM21615
Substrate/CompetitorBDBM21614
Meas. Tech.In Vitro GST Activity Assay
pH7.2±n/a
Temperature295.15±n/a K
IC50 890000±n/a nM
Citation Hohwy, MSpadola, LLundquist, BHawtin, PDahmén, JGroth-Clausen, INilsson, EPersdotter, Svon Wachenfeldt, KFolmer, RHEdman, K Novel prostaglandin d synthase inhibitors generated by fragment-based drug design. J Med Chem51:2178-86 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Hematopoietic prostaglandin D synthase
Name:Hematopoietic prostaglandin D synthase
Synonyms:GSTS | Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | HPGDS | HPGDS_HUMAN | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | PTGDS2 | Prostaglandin D | Prostaglandin D Synthase
Type:Enzyme
Mol. Mass.:23341.07
Organism:Homo sapiens (Human)
Description:The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag.
Residue:199
Sequence:
MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLT
LHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELL
TYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKK
VQAIPAVANWIKRRPQTKL
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BDBM21615
BDBM21614
NameBDBM21615
Synonyms:1-phenyl-1H-pyrazole-4-carboxylic acid | Pyrazole, 1
TypeSmall organic molecule
Emp. Form.C10H8N2O2
Mol. Mass.188.1827
SMILESOC(=O)c1cnn(c1)-c1ccccc1
Structure
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