| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 |
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| Ligand | BDBM370227 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | CDK6/Cyclin D1 Mobility Shift Assay |
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| Ki | 0.150±n/a nM |
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| Citation |  Freeman-Cook, KD; Hoffman, RL; Nagata, A; Ninkovic, S CDK2/4/6 inhibitors US Patent US10233188 Publication Date 3/19/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 |
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| Name: | Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 |
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| Synonyms: | CDK6/Cyclin D1 |
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| Type: | Enzyme |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Cyclin-dependent kinase 6 |
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| Synonyms: | CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 36937.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q00534 |
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| Residue: | 326 |
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| Sequence: | MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
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| Component 2 |
| Name: | G1/S-specific cyclin-D1 |
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| Synonyms: | CCND1_MOUSE | Ccnd1 | Cyclin D1 | Cyl-1 |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33418.84 |
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| Organism: | Mus musculus (mouse) |
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| Description: | n/a |
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| Residue: | 295 |
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| Sequence: | MEHQLLCCEVETIRRAYPDTNLLNDRVLRAMLKTEETCAPSVSYFKCVQKEIVPSMRKIV
ATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPLKKSRLQLLGATCMFVASKMKETIPLT
AEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEADENKQTIRK
HAQTFVALCATDVKFISNPPSMVAAGSVVAAMQGLNLGSPNNFLSCYRTTHFLSRVIKCD
PDCLRACQEQIEALLESSLRQAQQNVDPKATEEEGEVEEEAGLACTPTDVRDVDI
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| BDBM370227 |
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| n/a |
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| Name | BDBM370227 |
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| Synonyms: | US10233188, Example 114 | US10800783, Example 114 | US11396512, Example 114 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H33N5O5S |
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| Mol. Mass. | 479.593 |
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| SMILES | COCCS(=O)(=O)N1CCC(CC1)Nc1ncc2cc(C)c(=O)n([C@@H]3CCC[C@@]3(C)O)c2n1 |r| |
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| Structure | 
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