new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCDK6/Cyclin D1
LigandBDBM370227
Substrate/Competitorn/a
Meas. Tech.CDK6/Cyclin D1 Mobility Shift Assay
Ki 0.150±n/a nM
Citation Freeman-Cook KDHoffman RLNagata ANinkovic S CDK2/4/6 inhibitors US Patent  US10233188 Publication Date 3/19/2019
More Info.:Get all data from this article,  Assay Method
 
CDK6/Cyclin D1
Name:CDK6/Cyclin D1
Synonyms:n/a
Type:Enzyme
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Cyclin-dependent kinase 6
Synonyms:CDK6 | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE
Type:Enzyme Subunit
Mol. Mass.:36937.42
Organism:Homo sapiens (Human)
Description:Q00534
Residue:326
Sequence:
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
Component 2
Name:Cyclin D1
Synonyms:n/a
Type:Enzyme Subunit
Mol. Mass.:33418.84
Organism:Mus musculus (mouse)
Description:n/a
Residue:295
Sequence:
MEHQLLCCEVETIRRAYPDTNLLNDRVLRAMLKTEETCAPSVSYFKCVQKEIVPSMRKIV
ATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPLKKSRLQLLGATCMFVASKMKETIPLT
AEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEADENKQTIRK
HAQTFVALCATDVKFISNPPSMVAAGSVVAAMQGLNLGSPNNFLSCYRTTHFLSRVIKCD
PDCLRACQEQIEALLESSLRQAQQNVDPKATEEEGEVEEEAGLACTPTDVRDVDI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM370227
n/a
NameBDBM370227
Synonyms:US10233188, Example 114
TypeSmall organic molecule
Emp. Form.C22H33N5O5S
Mol. Mass.479.593
SMILESCOCCS(=O)(=O)N1CCC(CC1)Nc1ncc2cc(C)c(=O)n([C@@H]3CCC[C@@]3(C)O)c2n1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: