Reaction Details |
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Target | Nuclear receptor subfamily 1 group I member 2 |
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Ligand | BDBM21668 |
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Substrate/Competitor | BDBM21662 |
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Meas. Tech. | Competition Ligand Binding Assay and Transient Transfection Assay |
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pH | 8±n/a |
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Temperature | 295.15±n/a K |
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IC50 | 2512±n/a nM |
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EC50 | 10000±n/a nM |
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Citation | Xue, Y; Chao, E; Zuercher, WJ; Willson, TM; Collins, JL; Redinbo, MR Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism. Bioorg Med Chem15:2156-66 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Nuclear receptor subfamily 1 group I member 2 |
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Name: | Nuclear receptor subfamily 1 group I member 2 |
Synonyms: | NR1I2 | NR1I2_HUMAN | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | PXR | Pregnane X receptor | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1 |
Type: | Nuclear receptor |
Mol. Mass.: | 49774.77 |
Organism: | Homo sapiens (Human) |
Description: | O75469 |
Residue: | 434 |
Sequence: | MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG
CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE
RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSS
GCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLL
PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE
CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR
VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF
ATPLMQELFGITGS
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BDBM21668 |
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BDBM21662 |
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Name | BDBM21668 |
Synonyms: | N-[4-(1-hydroxyethyl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide | T0901317 analogue, 7 |
Type | Small organic molecule |
Emp. Form. | C16H16F3NO3S |
Mol. Mass. | 359.363 |
SMILES | CC(O)c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c1ccccc1 |
Structure |
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