Reaction Details | |||
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Target | Delta-type opioid receptor | ||
Ligand | BDBM21861 | ||
Substrate/Competitor | BDBM21864 | ||
Meas. Tech. | Radioligand Binding Assay | ||
Ki | >10000±n/a nM | ||
Citation | Mustazza, C; Borioni, A; Sestili, I; Sbraccia, M; Rodomonte, A; Del Giudice, MR Synthesis and pharmacological evaluation of 1,2-dihydrospiro[isoquinoline-4(3H),4'-piperidin]-3-ones as nociceptin receptor agonists. J Med Chem51:1058-62 (2008) [PubMed] Article | ||
More Info.: | Get all data from this article, Solution Info, Assay Method | ||
Delta-type opioid receptor | |||
Name: | Delta-type opioid receptor | ||
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 40382.98 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. | ||
Residue: | 372 | ||
Sequence: |
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BDBM21861 | |||
BDBM21864 | |||
Name | BDBM21861 | ||
Synonyms: | N-methyl-4-phenyl-1-[4-(propan-2-yl)cyclohexyl]piperidine-4-carboxamide | Piperidine Derivative, 4j | ||
Type | Small organic molecule | ||
Emp. Form. | C22H34N2O | ||
Mol. Mass. | 342.5182 | ||
SMILES | CNC(=O)C1(CCN(CC1)C1CCC(CC1)C(C)C)c1ccccc1 |(1.54,6.32,;.21,5.55,;.21,4.01,;1.54,3.24,;-1.12,3.24,;-2.46,2.47,;-2.46,.93,;-1.12,.16,;.21,.93,;.21,2.47,;-1.12,-1.38,;-2.46,-2.15,;-2.46,-3.69,;-1.12,-4.46,;.21,-3.69,;.21,-2.15,;-1.12,-6,;.21,-6.77,;-2.46,-6.77,;-2.46,4.01,;-2.46,5.55,;-3.79,6.32,;-5.13,5.55,;-5.13,4.01,;-3.79,3.24,)| | ||
Structure |