Reaction Details | |||
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Target | Kappa-type opioid receptor | ||
Ligand | BDBM21855 | ||
Substrate/Competitor | BDBM21865 | ||
Meas. Tech. | Radioligand Binding Assay | ||
Ki | 190±n/a nM | ||
Citation | Mustazza, C; Borioni, A; Sestili, I; Sbraccia, M; Rodomonte, A; Del Giudice, MR Synthesis and pharmacological evaluation of 1,2-dihydrospiro[isoquinoline-4(3H),4'-piperidin]-3-ones as nociceptin receptor agonists. J Med Chem51:1058-62 (2008) [PubMed] Article | ||
More Info.: | Get all data from this article, Solution Info, Assay Method | ||
Kappa-type opioid receptor | |||
Name: | Kappa-type opioid receptor | ||
Synonyms: | K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR) | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 42648.76 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P41145 | ||
Residue: | 380 | ||
Sequence: |
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BDBM21855 | |||
BDBM21865 | |||
Name | BDBM21855 | ||
Synonyms: | 2-benzyl-1'-(4-tert-butylcyclohexyl)-5-fluoro-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one | Piperidine Derivative, 5t | ||
Type | Small organic molecule | ||
Emp. Form. | C30H39FN2O | ||
Mol. Mass. | 462.6419 | ||
SMILES | CC(C)(C)C1CCC(CC1)N1CCC2(CC1)C(=O)N(Cc1ccccc1)Cc1cccc(F)c21 |(.21,-6.77,;-1.12,-6,;-2.46,-6.77,;-1.12,-7.54,;-1.12,-4.46,;-2.46,-3.69,;-2.46,-2.15,;-1.12,-1.38,;.21,-2.15,;.21,-3.69,;-1.12,.16,;-2.46,.93,;-2.46,2.47,;-1.12,3.24,;.21,2.47,;.21,.93,;.21,4.01,;1.54,3.24,;.21,5.55,;1.54,6.32,;1.54,7.86,;.21,8.63,;.21,10.17,;1.54,10.94,;2.88,10.17,;2.88,8.63,;-1.12,6.32,;-2.46,5.55,;-3.79,6.32,;-5.13,5.55,;-5.13,4.01,;-3.79,3.24,;-3.79,1.7,;-2.46,4.01,)| | ||
Structure |