| Reaction Details |
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 | Report a problem with these data |
| Target | Histone acetyltransferase KAT2B |
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| Ligand | BDBM371524 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PCAF AlphaLisa Binding Assay |
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| IC50 | 187±n/a nM |
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| Citation |  Albrecht, BK; Burdick, DJ; Cote, A; Duplessis, M; Nasveschuk, CG; Taylor, AM Therapeutic compounds and uses thereof US Patent US10239861 Publication Date 3/26/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone acetyltransferase KAT2B |
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| Name: | Histone acetyltransferase KAT2B |
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| Synonyms: | Histone acetyltransferase KAT2A/KAT2B | Histone acetyltransferase PCAF | KAT2B | KAT2B_HUMAN | PCAF |
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| Type: | PROTEIN |
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| Mol. Mass.: | 93045.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1502838 |
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| Residue: | 832 |
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| Sequence: | MSEAGGAGPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAAAAGGSGACGPATAVAA
AGTAEGPGGGGSARIAVKKAQLRSAPRAKKLEKLGVYSACKAEESCKCNGWKNPNPSPTP
PRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEED
ADTKQVYFYLFKLLRKSILQRGKPVVEGSLEKKPPFEKPSIEQGVNNFVQYKFSHLPAKE
RQTIVELAKMFLNRINYWHLEAPSQRRLRSPNDDISGYKENYTRWLCYCNVPQFCDSLPR
YETTQVFGRTLLRSVFTVMRRQLLEQARQEKDKLPLEKRTLILTHFPKFLSMLEEEVYSQ
NSPIWDQDFLSASSRTSQLGIQTVINPPPVAGTISYNSTSSSLEQPNAGSSSPACKASSG
LEANPGEKRKMTDSHVLEEAKKPRVMGDIPMELINEVMSTITDPAAMLGPETNFLSAHSA
RDEAARLEERRGVIEFHVVGNSLNQKPNKKILMWLVGLQNVFSHQLPRMPKEYITRLVFD
PKHKTLALIKDGRVIGGICFRMFPSQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKH
DILNFLTYADEYAIGYFKKQGFSKEIKIPKTKYVGYIKDYEGATLMGCELNPRIPYTEFS
VIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKDGVRQIPIESIPGIRETGWKPSGKEKSK
EPRDPDQLYSTLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLKNR
YYVSKKLFMADLQRVFTNCKEYNPPESEYYKCANILEKFFFSKIKEAGLIDK
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| BDBM371524 |
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| n/a |
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| Name | BDBM371524 |
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| Synonyms: | (racemic)-4-chloro-2-methyl-5-((1-methylazepan-4-yl)amino)pyridazin-3(2H)-one | US10239861, Example 4 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H19ClN4O |
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| Mol. Mass. | 270.758 |
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| SMILES | CN1CCCC(CC1)Nc1cnn(C)c(=O)c1Cl |
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| Structure | 
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