Reaction Details |
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Target | Indoleamine 2,3-dioxygenase 1 |
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Ligand | BDBM21973 |
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Substrate/Competitor | BDBM21974 |
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Meas. Tech. | Enzyme Inhibition Assay |
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pH | 6.5±n/a |
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Temperature | 310.15±n/a K |
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Ki | 62000±7000 nM |
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Citation | Carr, G; Chung, MK; Mauk, AG; Andersen, RJ Synthesis of indoleamine 2,3-dioxygenase inhibitory analogues of the sponge alkaloid exiguamine a. J Med Chem51:2634-7 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Indoleamine 2,3-dioxygenase 1 |
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Name: | Indoleamine 2,3-dioxygenase 1 |
Synonyms: | I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase |
Type: | Enzyme |
Mol. Mass.: | 45330.80 |
Organism: | Homo sapiens (Human) |
Description: | P14902 |
Residue: | 403 |
Sequence: | MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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BDBM21973 |
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BDBM21974 |
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Name | BDBM21973 |
Synonyms: | 1-Methyltryptophan, 1 | 2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid |
Type | Small organic molecule |
Emp. Form. | C12H14N2O2 |
Mol. Mass. | 218.2518 |
SMILES | Cn1cc(CC(N)C(O)=O)c2ccccc12 |
Structure |
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