| Reaction Details |
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 | Report a problem with these data |
| Target | Monocarboxylate transporter 1 |
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| Ligand | BDBM21990 |
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| Substrate/Competitor | BDBM21986 |
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| Meas. Tech. | Radioligand Filter Binding Assay |
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| pH | 7.8±n/a |
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| Temperature | 295.15±n/a K |
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| Ki | 59±n/a nM |
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| Citation |  Guile, SD; Bantick, JR; Cooper, ME; Donald, DK; Eyssade, C; Ingall, AH; Lewis, RJ; Martin, BP; Mohammed, RT; Potter, TJ; Reynolds, RH; St-Gallay, SA; Wright, AD Optimization of monocarboxylate transporter 1 blockers through analysis and modulation of atropisomer interconversion properties. J Med Chem50:254-63 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Monocarboxylate transporter 1 |
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| Name: | Monocarboxylate transporter 1 |
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| Synonyms: | MCT 1 | MCT1 | MOT1_HUMAN | Monocarboxylate transporter 1 | SLC16A1 | Solute carrier family 16 member 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53956.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1451367 |
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| Residue: | 500 |
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| Sequence: | MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATTSEVSW
ISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIG
GLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLI
LGGLLLNCCVAGALMRPIGPKPTKAGKDKSKASLEKAGKSGVKKDLHDANTDLIGRHPKQ
EKRSVFQTINQFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAF
LLSILAFVDMVARPSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYA
GFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYK
YTYWACGVVLIISGIYLFIGMGINYRLLAKEQKANEQKKESKEEETSIDVAGKPNEVTKA
AESPDQKDTDGGPKEEESPV
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| BDBM21990 |
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| BDBM21986 |
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| Name | BDBM21990 |
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| Synonyms: | 5-(azetidin-1-ylcarbonyl)-3-methyl-6-{[2-(methylamino)-1H-1,3-benzodiazol-1-yl]methyl}-1-(2-methylpropyl)-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione | Thienopyrimidine-2,4-dione, 5 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H28N6O3S |
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| Mol. Mass. | 480.583 |
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| SMILES | CNc1nc2ccccc2n1Cc1sc2n(CC(C)C)c(=O)n(C)c(=O)c2c1C(=O)N1CCC1 |
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| Structure | 
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