Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetMonocarboxylate Transporter 1
LigandBDBM22024
Substrate/CompetitorBDBM22022
Meas. Tech.SPA Assay
pH7.4±n/a
Temperature295.15±n/a K
Ki 3.9±n/a nM
Citation Guile SDBantick JRCheshire DRCooper MEDavis AMDonald DKEvans REyssade CFerguson DDHill SHutchinson RIngall AHKingston LPMartin IMartin BPMohammed RTMurray CPerry MWReynolds RHThorne PVWilkinson DJWithnall J Potent blockers of the monocarboxylate transporter MCT1: novel immunomodulatory compounds. Bioorg Med Chem Lett 16:2260-5 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Monocarboxylate Transporter 1
Name:Monocarboxylate transporter 1
Synonyms:MCT 1 | Solute carrier family 16 member 1
Type:PROTEIN
Mol. Mass.:53956.64
Organism:Homo sapiens (Human)
Description:ChEMBL_1451367
Residue:500
Sequence:
MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATTSEVSW
ISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIG
GLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLI
LGGLLLNCCVAGALMRPIGPKPTKAGKDKSKASLEKAGKSGVKKDLHDANTDLIGRHPKQ
EKRSVFQTINQFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAF
LLSILAFVDMVARPSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYA
GFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYK
YTYWACGVVLIISGIYLFIGMGINYRLLAKEQKANEQKKESKEEETSIDVAGKPNEVTKA
AESPDQKDTDGGPKEEESPV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM22024
BDBM22022
NameBDBM22024
Synonyms:5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-6-(isoquinolin-4-ylmethyl)-3-methyl-1-(2-methylpropyl)-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione | Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 32
TypeSmall organic molecule
Emp. Form.C26H28N4O4S
Mol. Mass.492.59
SMILESCC(C)Cn1c2sc(Cc3cncc4ccccc34)c(C(=O)N3CC[C@@H](O)C3)c2c(=O)n(C)c1=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: