| Reaction Details |
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 | Report a problem with these data |
| Target | Monocarboxylate transporter 1 |
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| Ligand | BDBM22028 |
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| Substrate/Competitor | BDBM22022 |
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| Meas. Tech. | SPA Assay |
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| pH | 7.4±n/a |
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| Temperature | 295.15±n/a K |
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| Ki | 16±n/a nM |
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| Citation |  Guile, SD; Bantick, JR; Cheshire, DR; Cooper, ME; Davis, AM; Donald, DK; Evans, R; Eyssade, C; Ferguson, DD; Hill, S; Hutchinson, R; Ingall, AH; Kingston, LP; Martin, I; Martin, BP; Mohammed, RT; Murray, C; Perry, MW; Reynolds, RH; Thorne, PV; Wilkinson, DJ; Withnall, J Potent blockers of the monocarboxylate transporter MCT1: novel immunomodulatory compounds. Bioorg Med Chem Lett16:2260-5 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Monocarboxylate transporter 1 |
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| Name: | Monocarboxylate transporter 1 |
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| Synonyms: | MCT 1 | MCT1 | MOT1_HUMAN | Monocarboxylate transporter 1 | SLC16A1 | Solute carrier family 16 member 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53956.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1451367 |
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| Residue: | 500 |
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| Sequence: | MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATTSEVSW
ISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIG
GLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLI
LGGLLLNCCVAGALMRPIGPKPTKAGKDKSKASLEKAGKSGVKKDLHDANTDLIGRHPKQ
EKRSVFQTINQFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAF
LLSILAFVDMVARPSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYA
GFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYK
YTYWACGVVLIISGIYLFIGMGINYRLLAKEQKANEQKKESKEEETSIDVAGKPNEVTKA
AESPDQKDTDGGPKEEESPV
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| BDBM22028 |
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| BDBM22022 |
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| Name | BDBM22028 |
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| Synonyms: | 5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-3-methyl-6-[(2-methyl-1H-1,3-benzodiazol-1-yl)methyl]-1-(2-methylpropyl)-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione | Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 36 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H29N5O4S |
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| Mol. Mass. | 495.594 |
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| SMILES | CC(C)Cn1c2sc(Cn3c(C)nc4ccccc34)c(C(=O)N3CC[C@@H](O)C3)c2c(=O)n(C)c1=O |r| |
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| Structure | 
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