Reaction Details |
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Target | Nitric oxide synthase, endothelial [N368D] |
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Ligand | BDBM21960 |
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Substrate/Competitor | BDBM21959 |
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Meas. Tech. | NOS Enzyme Inhibition Assay |
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pH | 7.5±n/a |
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Temperature | 303.15±n/a K |
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Ki | 4600±n/a nM |
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Citation | Flinspach, ML; Li, H; Jamal, J; Yang, W; Huang, H; Hah, JM; Giómez-Vidal, JA; Litzinger, EA; Silverman, RB; Poulos, TL Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase. Nat Struct Mol Biol11:54-9 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Nitric oxide synthase, endothelial [N368D] |
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Name: | Nitric oxide synthase, endothelial [N368D] |
Synonyms: | Constitutive NOS | Endothelial NOS | Endothelial nitric oxide synthase | NOS type III | NOS3 | NOS3_BOVIN | Nitric Oxide Synthase, endothelial Mutant (N368D) | cNOS |
Type: | Enzyme |
Mol. Mass.: | 133292.24 |
Organism: | Bos taurus (bovine) |
Description: | Recombinant enzyme overexpressed in E. coli. |
Residue: | 1205 |
Sequence: | MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPAPEPSRAPAPATPHAPDHSPAPNSPT
LTRPPEGPKFPRVKNWELGSITYDTLCAQSQQDGPCTPRCCLGSLVLPRKLQTRPSPGPP
PAEQLLSQARDFINQYYSSIKRSGSQAHEERLQEVEAEVASTGTYHLRESELVFGAKQAW
RNAPRCVGRIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPGR
GDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDE
APELFVLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFSAAPFSGWYM
STEIGTRDLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSFQLAKVTIV
DHHAATVSFMKHLDNEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYILSPAFRYQPD
PWKGSATKGAGITRKKTFKEVANAVKISASLMGTLMAKRVKATILYASETGRAQSYAQQL
GRLFRKAFDPRVLCMDEYDVVSLEHEALVLVVTSTFGNGDPPENGESFAAALMEMSGPYN
SSPRPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYP
HFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAKAAFQASCETFCVGEEAKA
AAQDIFSPKRSWKRQRYRLSTQAEGLQLLPGLIHVHRRKMFQATVLSVENLQSSKSTRAT
ILVRLDTAGQEGLQYQPGDHIGICPPNRPGLVEALLSRVEDPPPPTESVAVEQLEKGSPG
GPPPSWVRDPRLPPCTLRQALTFFLDITSPPSPRLLRLLSTLAEEPSEQQELETLSQDPR
RYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPNAHPGEVHLTVA
VLAYRTQDGLGPLHYGVCSTWLSQLKTGDPVPCFIRGAPSFRLPPDPYVPCILVGPGTGI
APFRGFWQERLHDIESKGLQPAPMTLVFGCRCSQLDHLYRDEVQDAQERGVFGRVLTAFS
REPDSPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATSVLQTVQRILATEGDME
LDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERHLRGAVPWAFDPPGP
DTPGP
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BDBM21960 |
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BDBM21959 |
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Name | BDBM21960 |
Synonyms: | 3-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-1-nitroguanidine | CHEMBL227937 | JMC522060 Compound 2 | N omega-Nitro-L-Arginine-Containing Dipeptide, 1 |
Type | n/a |
Emp. Form. | C8H21N7O2 |
Mol. Mass. | 247.298 |
SMILES | NCCNC[C@@H](N)CCCN=C(N)N[N+]([O-])=O |w:10.9| |
Structure |
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