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Reaction Details
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TargetTranslocator protein
LigandBDBM22041
Substrate/CompetitorBDBM22032
Meas. Tech.Radioligand Binding Assay
pH7.4±n/a
Temperature277.15±n/a K
Ki 0.5±n/a nM
CommentsThe measured Ki, taken from J. Md. Chem. 2004, 47, 1852 was 0.5 nM - 7 nM.
Citation Taliani, SSimorini, FSergianni, VLa Motta, CDa Settimo, FCosimelli, BAbignente, EGreco, GNovellino, ERossi, LGremigni, VSpinetti, FChelli, BMartini, C New fluorescent 2-phenylindolglyoxylamide derivatives as probes targeting the peripheral-type benzodiazepine receptor: design, synthesis, and biological evaluation. J Med Chem50:404-7 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Translocator protein
Name:Translocator protein
Synonyms:Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:Mitochondrion membrane protein
Mol. Mass.:18945.84
Organism:Rattus norvegicus (rat)
Description:Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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  Blast E-value cutoff:
BDBM22041
BDBM22032
NameBDBM22041
Synonyms:2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]-N,N-dipropylacetamide | Alpidem | Ananxyl | CHEMBL54349 | S-800342
TypeSmall organic molecule
Emp. Form.C21H23Cl2N3O
Mol. Mass.404.333
SMILESCCCN(CCC)C(=O)Cc1c(nc2ccc(Cl)cn12)-c1ccc(Cl)cc1
Structure
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