Reaction Details |
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Target | Translocator protein |
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Ligand | BDBM22041 |
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Substrate/Competitor | BDBM22032 |
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Meas. Tech. | Radioligand Binding Assay |
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pH | 7.4±n/a |
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Temperature | 277.15±n/a K |
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Ki | 0.5±n/a nM |
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Comments | The measured Ki, taken from J. Md. Chem. 2004, 47, 1852 was 0.5 nM - 7 nM. |
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Citation | Taliani, S; Simorini, F; Sergianni, V; La Motta, C; Da Settimo, F; Cosimelli, B; Abignente, E; Greco, G; Novellino, E; Rossi, L; Gremigni, V; Spinetti, F; Chelli, B; Martini, C New fluorescent 2-phenylindolglyoxylamide derivatives as probes targeting the peripheral-type benzodiazepine receptor: design, synthesis, and biological evaluation. J Med Chem50:404-7 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Translocator protein |
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Name: | Translocator protein |
Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
Type: | Mitochondrion membrane protein |
Mol. Mass.: | 18945.84 |
Organism: | Rattus norvegicus (rat) |
Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
Residue: | 169 |
Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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BDBM22041 |
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BDBM22032 |
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Name | BDBM22041 |
Synonyms: | 2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]-N,N-dipropylacetamide | Alpidem | Ananxyl | CHEMBL54349 | S-800342 |
Type | Small organic molecule |
Emp. Form. | C21H23Cl2N3O |
Mol. Mass. | 404.333 |
SMILES | CCCN(CCC)C(=O)Cc1c(nc2ccc(Cl)cn12)-c1ccc(Cl)cc1 |
Structure |
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