| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin B-like cysteine protease |
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| Ligand | BDBM22090 |
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| Substrate/Competitor | BDBM22047 |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | >25000±n/a nM |
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| Comments | extracted |
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| Citation |  Mallari, JP; Shelat, AA; Obrien, T; Caffrey, CR; Kosinski, A; Connelly, M; Harbut, M; Greenbaum, D; McKerrow, JH; Guy, RK Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB. J Med Chem51:545-52 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Cathepsin B-like cysteine protease |
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| Name: | Cathepsin B-like cysteine protease |
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| Synonyms: | CPC | Cathepsin B-Like Cysteine Protease (TbcatB) | Cysteine peptidase C | TbcatB |
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| Type: | Enzyme |
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| Mol. Mass.: | 37220.37 |
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| Organism: | Trypanosoma brucei |
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| Description: | Enzyme was expressed in yeast Pichia pastoris. |
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| Residue: | 340 |
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| Sequence: | MHLMRACITFCIASTAVVAVNAALVAEDAPVLSKAFVDRVNRLNRGIWKAKYDGVMQNIT
LREAKRLNGVIKKNNNASILPKRRFTEEEARAPLPSSFDSAEAWPNCPTIPQIADQSACG
SCWAVAAASAMSDRFCTMGGVQDVHISAGDLLACCSDCGDGCNGGDPDRAWAYFSSTGLV
SDYCQPYPFPHCSHHSKSKNGYPPCSQFNFDTPKCNYTCDDPTIPVVNYRSWTSYALQGE
DDYMRELFFRGPFEVAFDVYEDFIAYNSGVYHHVSGQYLGGHAVRLVGWGTSNGVPYWKI
ANSWNTEWGMDGYFLIRRGSSECGIEDGGSAGIPLAPNTA
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| BDBM22090 |
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| BDBM22047 |
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| Name | BDBM22090 |
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| Synonyms: | 6-{[(4-chlorophenyl)methyl]amino}-9-{[3-(trifluoromethyl)phenyl]methyl}-9H-purine-2-carbonitrile | Compound 3{10,18} |
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| Type | Small organic molecule |
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| Emp. Form. | C21H14ClF3N6 |
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| Mol. Mass. | 442.824 |
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| SMILES | FC(F)(F)c1cccc(Cn2cnc3c(NCc4ccc(Cl)cc4)nc(nc23)C#N)c1 |
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| Structure | 
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