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TargetCathepsin B-like cysteine protease
LigandBDBM22092
Substrate/CompetitorBDBM22047
Meas. Tech.Enzyme Inhibition Assay
Temperature298.15±n/a K
IC50>25000±n/a nM
Commentsextracted
Citation Mallari, JPShelat, AAObrien, TCaffrey, CRKosinski, AConnelly, MHarbut, MGreenbaum, DMcKerrow, JHGuy, RK Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB. J Med Chem51:545-52 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Cathepsin B-like cysteine protease
Name:Cathepsin B-like cysteine protease
Synonyms:CPC | Cathepsin B-Like Cysteine Protease (TbcatB) | Cysteine peptidase C | TbcatB
Type:Enzyme
Mol. Mass.:37220.37
Organism:Trypanosoma brucei
Description:Enzyme was expressed in yeast Pichia pastoris.
Residue:340
Sequence:
MHLMRACITFCIASTAVVAVNAALVAEDAPVLSKAFVDRVNRLNRGIWKAKYDGVMQNIT
LREAKRLNGVIKKNNNASILPKRRFTEEEARAPLPSSFDSAEAWPNCPTIPQIADQSACG
SCWAVAAASAMSDRFCTMGGVQDVHISAGDLLACCSDCGDGCNGGDPDRAWAYFSSTGLV
SDYCQPYPFPHCSHHSKSKNGYPPCSQFNFDTPKCNYTCDDPTIPVVNYRSWTSYALQGE
DDYMRELFFRGPFEVAFDVYEDFIAYNSGVYHHVSGQYLGGHAVRLVGWGTSNGVPYWKI
ANSWNTEWGMDGYFLIRRGSSECGIEDGGSAGIPLAPNTA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM22092
BDBM22047
NameBDBM22092
Synonyms:9-benzyl-6-{[(4-bromophenyl)methyl]amino}-9H-purine-2-carbonitrile | Compound 3{11,17}
TypeSmall organic molecule
Emp. Form.C20H15BrN6
Mol. Mass.419.277
SMILESBrc1ccc(CNc2nc(nc3n(Cc4ccccc4)cnc23)C#N)cc1
Structure
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